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Temporal trends and predictors of perfluoroalkyl substances serum levels in Swedish pregnant women in the SELMA study

PloS one, 2018, Vol.13 (12), p.e0209255-e0209255 [Peer Reviewed Journal]

2018 Shu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2018 Shu et al 2018 Shu et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0209255 ;PMID: 30596681

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Title:
Temporal trends and predictors of perfluoroalkyl substances serum levels in Swedish pregnant women in the SELMA study
Author: Shu, Huan ; Lindh, Christian H ; Wikström, Sverre ; Bornehag, Carl-Gustaf
Ng, Carla A.
Subjects: Acids ; Adult ; Age ; Age Factors ; Animals ; Arbetsmedicin och miljömedicin ; Bioaccumulation ; Biology and Life Sciences ; Children ; Clinical Medicine ; Consumer products ; Cotinine - blood ; Diet ; Disruption ; Endocrine disruptors ; Environmental Health and Occupational Health ; Environmental Pollutants - blood ; Female ; Fish ; Fishes ; Fluorocarbons - blood ; Folkhälsovetenskap ; Health risk assessment ; Health risks ; Health Sciences ; Humans ; Hälsovetenskap ; Jet Lag Syndrome ; Klinisk medicin ; Longitudinal Studies ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Medicine and Health Sciences ; Obstetrics, Gynecology and Reproductive Medicine ; Organic chemistry ; Parity ; People and places ; Perfluoro compounds ; Perfluoroalkyls ; Perfluorodecanoic acid ; Perfluorohexane ; Perfluorooctanoic acid ; Physical Sciences ; Pregnancy ; Public Health Science ; Reproduktionsmedicin och gynekologi ; Research and Analysis Methods ; Seafood ; Serum levels ; Smoking ; Smoking - blood ; Sweden - epidemiology ; Trends ; Womens health
Is Part Of: PloS one, 2018, Vol.13 (12), p.e0209255-e0209255
Description: Perfluoroalkyl substances (PFAS) are used in numerous consumer products. They are persistent, bioaccumulating, and suspected to be endocrine disrupting chemicals (EDCs). A growing body of research has reported the association between PFAS exposure and adverse health effects. Concerns have been raised with special focus in childhood development. Perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), perfluorohexane sulfonate (PFHxS) and perfluorooctane sulfonate (PFOS) were analyzed by LC/MS/MS in serum from 1,616 pregnant women in the Swedish SELMA study. The serum samples were collected in the first trimester (median week 10). Least square geometric means (LSGM) of PFAS were estimated for each year period for, adjusted for potential determinants including parity, fish intake in the family, and mother's age. Six PFAS (PFNA, PFDA, PFUnDA, PFHxS, PFOA, and PFOS) were detected above levels of detection (LOD) in more than 99% of the SELMA women, while PFHpA, and PFDoDA were detected above LOD in 73.4% and 46.7% respectively. Parity, maternal age, maternal smoking, and fish intake during pregnancy were found to be significantly associated (p<0.05) with serum PFAS levels in the pregnant women. Finally, serum concentration of six PFAS (PFNA, PFDA, PFHxS, PFHpA, PFOA and PFOS) were significantly decreasing (range 14-31%) during the period of 30 months from 2007-2010. Our analysis shows that six out of eight PFAS could be identified in serum of more than 99% of SELMA subjects with a significant slightly decreasing trend for five of these compounds. Furthermore, parity, higher fish intake and mothers age are determinants for serum levels of PFAS in pregnant women.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0209255
PMID: 30596681
Source: PubMed Central (Open access)
DOAJ Directory of Open Access Journals
Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
MEDLINE
SWEPUB Freely available online
Public Library of Science

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Temporal trends and predictors of perfluoroalkyl substances serum levels in Swedish pregnant women in the SELMA study

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