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Maternal demographics and hemodynamics for the prediction of fetal growth restriction at booking, in pregnancies at high risk for placental insufficiency

Acta obstetricia et gynecologica Scandinavica, 2016-03, Vol.95 (3), p.329-338 [Peer Reviewed Journal]

2015 Nordic Federation of Societies of Obstetrics and Gynecology ;2015 Nordic Federation of Societies of Obstetrics and Gynecology. ;Acta Obstetricia et Gynecologica Scandinavica © 2016 Nordic Federation of Societies of Obstetrics and Gynecology ;ISSN: 0001-6349 ;EISSN: 1600-0412 ;DOI: 10.1111/aogs.12823 ;PMID: 26599800 ;CODEN: AOGSAE

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Title:
Maternal demographics and hemodynamics for the prediction of fetal growth restriction at booking, in pregnancies at high risk for placental insufficiency
Author: Stott, Daniel ; Bolten, Mareike ; Salman, Mona ; Paraschiv, Daniela ; Clark, Katherine ; Kametas, Nikos A.
Subjects: Adult ; Area Under Curve ; bioreactance ; Birth Weight ; Body Height ; Body Surface Area ; Cardiac Output ; Chronic Disease ; Demography ; European Continental Ancestry Group ; Female ; Fetal growth restriction ; Fetal Growth Retardation - diagnosis ; Fetal Growth Retardation - ethnology ; Fetal Growth Retardation - etiology ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - ethnology ; Hypertension - physiopathology ; Hypertension, Pregnancy-Induced - physiopathology ; Infant, Low Birth Weight ; Infant, Newborn ; peripheral vascular resistance ; Predictive Value of Tests ; Pregnancy ; Pregnancy, High-Risk ; Prenatal Care ; Prospective Studies ; ROC Curve ; Vascular Resistance
Is Part Of: Acta obstetricia et gynecologica Scandinavica, 2016-03, Vol.95 (3), p.329-338
Description: Introduction Fetal growth restriction (FGR) is associated with poor perinatal outcomes. Screening and prevention tools for FGR, such as uterine artery Doppler imaging and aspirin, underperform in high‐risk groups, compared with general antenatal populations. There is a paucity of sensitive screening tests for the early prediction of FGR in high‐risk pregnancies. Materials and Methods This was a prospective observational study based in a dedicated antenatal hypertension clinic at a tertiary UK hospital. We assessed maternal demographic and central hemodynamic variables as predictors for FGR in a group of women at high risk for placental insufficiency due to chronic hypertension (n = 55) or a history of hypertension in a previous pregnancy (n = 71). Outcome variables were birthweight z‐score as well as development of FGR (defined as birthweight below the 5th or 3rd centile). Maternal hemodynamics were assessed using a noninvasive transthoracic bioreactance monitor (Cheetah NICOM). Results The mean gestation at presentation was 13.6 (range: 8.5–19.5) weeks. Sixteen women delivered babies below the 5th centile. Ten of these were below the 3rd centile. Independent predictors of birthweight z‐score were body surface area, peripheral vascular resistance and white ethnicity (R2 = 0.26, p < 0.0001). Independent predictors of FGR were maternal height and cardiac output. The area under the receiver operator characteristic curve for prediction of FGR was 0.915 (95% CI 0.859–0.972) and 0.9079 (95% CI 0.823–0.990) for FGR below the 5th and 3rd centiles, respectively. Conclusion In women with chronic hypertension or a history of hypertension in a previous pregnancy, maternal size and cardiac output at booking provide a sensitive screening tool for FGR.
Publisher: United States: Blackwell Publishing Ltd
Language: English;French;German
Identifier: ISSN: 0001-6349
EISSN: 1600-0412
DOI: 10.1111/aogs.12823
PMID: 26599800
CODEN: AOGSAE
Source: Journals@Ovid Open Access Journal Collection Rolling
MEDLINE
Alma/SFX Local Collection

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Maternal demographics and hemodynamics for the prediction of fetal growth restriction at booking, in pregnancies at high risk for placental insufficiency

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