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Effect of Rosuvastatin on Coronary Atheroma in Stable Coronary Artery Disease: Multicenter Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS)

Circulation Journal, 2009, Vol.73(11), pp.2110-2117 [Peer Reviewed Journal]

2009 THE JAPANESE CIRCULATION SOCIETY ;ISSN: 1346-9843 ;EISSN: 1347-4820 ;DOI: 10.1253/circj.CJ-09-0358 ;PMID: 19801853

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Title:
Effect of Rosuvastatin on Coronary Atheroma in Stable Coronary Artery Disease: Multicenter Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS)
Author: Takayama, Tadateru ; Hiro, Takafumi ; Yamagishi, Masakazu ; Daida, Hiroyuki ; Hirayama, Atsushi ; Saito, Satoshi ; Yamaguchi, Tetsu ; Matsuzaki, Masunori ; Investigators, The COSMOS
Subjects: Aged ; Asian Continental Ancestry Group ; Atherosclerosis ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Coronary artery disease (CAD) ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - drug therapy ; Female ; Fluorobenzenes - therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Intravascular ultrasound (IVUS) ; Japan ; Lipid-lowering therapy ; Male ; Middle Aged ; Pyrimidines - therapeutic use ; Rosuvastatin ; Rosuvastatin Calcium ; Sulfonamides - therapeutic use ; Ultrasonography, Interventional
Is Part Of: Circulation Journal, 2009, Vol.73(11), pp.2110-2117
Description: Background: It has been suggested that intensive lipid-lowering therapy using statins significantly decreases atheromatous plaque volume. The effect of rosuvastatin on plaque volume in patients with stable coronary artery disease (CAD), including those receiving prior lipid-lowering therapy, was examined in the present study. Methods and Results: A 76-week open-label trial was performed at 37 centers in Japan. Eligible patients began treatment with rosuvastatin 2.5 mg/day, which could be increased at 4-week intervals to ≤20 mg/day. A total of 214 patients underwent intravascular ultrasound (IVUS) at baseline; 126 patients had analyzable IVUS images at the end of the study. The change in the serum low-density lipoprotein-cholesterol level from baseline to end of follow-up was -38.6 ±16.9%, whereas that of high-density lipoprotein-cholesterol was +19.8 ±22.9% (both P<0.0001). Percent change of plaque volume, the primary endpoint, was -5.1 ±14.1% (P<0.0001). Conclusions: Rosuvastatin exerted significant regression of coronary plaque volume in Japanese patients with stable CAD, including those who had previously used other lipid-lowering drugs. Rosuvastatin might be useful in the setting of secondary prevention in patients with stable CAD. (Circ J 2009; 73: 2110-2117)
Publisher: Japan: The Japanese Circulation Society
Language: English
Identifier: ISSN: 1346-9843
EISSN: 1347-4820
DOI: 10.1253/circj.CJ-09-0358
PMID: 19801853
Source: GFMER Free Medical Journals
MEDLINE
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Effect of Rosuvastatin on Coronary Atheroma in Stable Coronary Artery Disease: Multicenter Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS)

2009 THE JAPANESE CIRCULATION SOCIETY ;ISSN: 1346-9843 ;EISSN: 1347-4820 ;DOI: 10.1253/circj.CJ-09-0358 ;PMID: 19801853

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