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Correlations Between Coronary Artery Disease, Coronary Artery Calcium Score, and Lipoprotein(a) Level in Korea

Therapeutics and clinical risk management, 2022-10, Vol.18, p.981-987 [Peer Reviewed Journal]

COPYRIGHT 2022 Dove Medical Press Limited ;2022. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2022 Kim et al. 2022 Kim et al. ;ISSN: 1178-203X ;ISSN: 1176-6336 ;EISSN: 1178-203X ;DOI: 10.2147/TCRM.S374372

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Title:
Correlations Between Coronary Artery Disease, Coronary Artery Calcium Score, and Lipoprotein(a) Level in Korea
Author: Kim, Joan ; Choi, Seung Woo ; Lee, Young Shin ; Lee, Jung Myung ; Chung, Hyemoon ; Woo, Jong Shin ; Kim, Woo-Shik ; Choi, Yun Young ; Kim, Weon
Subjects: Age ; Angiography ; Apolipoproteins ; Cardiac patients ; Cardiovascular disease ; Care and treatment ; Cholesterol ; Coronary artery bypass ; coronary artery disease ; coronary calcium score ; Coronary heart disease ; Coronary vessels ; CT imaging ; Heart surgery ; Lipids ; Lipoprotein A ; Lipoproteins ; Medical imaging ; Medical research ; Medicine, Experimental ; Metabolism ; Original Research ; Risk factors ; Statistical analysis ; Stroke ; Tomography ; Type 2 diabetes ; Vein & artery diseases
Is Part Of: Therapeutics and clinical risk management, 2022-10, Vol.18, p.981-987
Description: Background: Lipoprotein(a) (Lp(a)) levels are associated with coronary artery disease (CAD) and aortic valve calcification. This study aimed to determine the correlation between Lp(a) levels and coronary artery calcium (CAC) scores in patients who underwent coronary computed tomography angiography (CCTA). Methods: This was a single-center observational study. The patients had not been previously diagnosed with CAD and underwent CCTA and Lp(a) measurement in a three-month timeframe. Coronary angiography and further management were performed according to the physician's decision. Of the 252 patients, 81 and 171 patients underwent coronary revascularization and received medical treatment only, respectively. To examine the relationship between Lp(a) and CAC score and between Lp(a) and CAD, we divided the patients by Lp(a) level (50 mg/dL) and CAC score (400). Results: No relationship was observed between Lp(a) and CAD or other risk factors for CAD. There were no differences in the ratio of patients who underwent coronary revascularization or in the CAC score according to an Lp(a) level of 50 mg/dL. There was no difference in Lp(a) level at a CAC score of 400. The proportion of patients who underwent coronary revascularization was high in the high CAC score group (50.6% vs 23.7%, p = 0.000). No association was observed between Lp(a) level and CAC score in the Spearman correlation (0.000, p < 0.998). Conclusion: Correlations between Lp(a) level and CAC score and between Lp(a) and CAD were not observed in this Korean cohort study. However, a high CAC score was correlated with coronary revascularization. Keywords: lipoprotein(a), coronary calcium score, coronary artery disease
Publisher: Macclesfield: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1178-203X
ISSN: 1176-6336
EISSN: 1178-203X
DOI: 10.2147/TCRM.S374372
Source: Geneva Foundation Free Medical Journals at publisher websites
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals
Dove Press Free

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Correlations Between Coronary Artery Disease, Coronary Artery Calcium Score, and Lipoprotein(a) Level in Korea

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