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Myofascial edema of gastrocnemius: A prominent MRI characteristic in dermatomyositis patients with anti‐transcriptional intermediate factor 1‐γ antibody

CNS neuroscience & therapeutics, 2024-02, Vol.30 (2), p.e14647-n/a [Peer Reviewed Journal]

2024 The Authors. published by John Wiley & Sons Ltd. ;2024 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. ;2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1755-5930 ;EISSN: 1755-5949 ;DOI: 10.1111/cns.14647 ;PMID: 38385674

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Title:
Myofascial edema of gastrocnemius: A prominent MRI characteristic in dermatomyositis patients with anti‐transcriptional intermediate factor 1‐γ antibody
Author: Zhen, Chao ; Zhao, Bing ; He, Jingzhen ; Wei, Li ; Yan, Chuanzhu ; Dai, Tingjun ; Hou, Ying
Subjects: Adult ; anti‐TIF1‐γ dermatomyositis ; Atrophy ; Biopsy ; Cloning ; Creatine ; Creatine kinase ; Cross-Sectional Studies ; Dermatomyositis ; Dermatomyositis - complications ; Dermatomyositis - diagnostic imaging ; Disease ; Dysphagia ; Edema ; Edema - diagnostic imaging ; Edema - pathology ; fatty replacement ; Humans ; Kinases ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Monasteries ; Monoclonal antibodies ; muscle edema ; Muscle, Skeletal - diagnostic imaging ; Muscle, Skeletal - pathology ; Muscles ; myofascial edema ; Original ; Patients ; Retrospective Studies
Is Part Of: CNS neuroscience & therapeutics, 2024-02, Vol.30 (2), p.e14647-n/a
Description: Aims This study was designed to evaluate the magnetic resonance imaging (MRI) patterns of the lower limb muscles in dermatomyositis (DM) with anti‐transcriptional intermediate factor 1‐γ (anti‐TIF1‐γ) antibody. Methods This retrospective, observational, cross‐sectional study enrolled 12 adult DM patients with anti‐TIF1‐γ antibody. Muscles were assessed for fascial edema, subcutaneous‐tissue edema, muscle edema, and fatty replacement. These features were analyzed in relation to clinical characteristics. Results All 12 patients underwent hip and thigh MRI, and 8 completed calf MRI. All patients showed myofascial edema, muscle edema, and fatty replacement, and 8 out of 12 further exhibited subcutaneous‐tissue edema. Specifically, myofascial edema of the gastrocnemius was observed in all patients (8/8). The vastus intermedialis and vastus lateralis muscles showed the most severe muscle edema, whereas the caput breve of the biceps femoris, semitendinosus, and soleus muscles exhibited the most severe fatty replacement. Although only 1 patient exhibited asymmetric muscle weakness, 9 showed asymmetric muscle edema, and 10 showed asymmetric fatty replacement. Changes in muscle edema positively correlated with creatine kinase (CK) levels. Conclusions Myofascial edema of gastrocnemius was a prominent characteristic of anti‐TIF1‐γ‐positive DM. Early detection of muscle edema, as well as CK levels, may be helpful for monitoring disease activity. All patients with anti‐TIF‐1γ antibody showed myofascial edema, muscle edema, and fatty replacement of lower limb muscles. Myofascial edema of gastrocnemius was a prominent characteristic of this population, and muscle edema could serve as a sensitive biomarker for monitoring disease activity.
Publisher: England: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 1755-5930
EISSN: 1755-5949
DOI: 10.1111/cns.14647
PMID: 38385674
Source: Journals@Ovid Open Access Journal Collection Rolling
PubMed Central (Open access)
DOAJ Directory of Open Access Journals
AUTh Library subscriptions: ProQuest Central
MEDLINE

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Myofascial edema of gastrocnemius: A prominent MRI characteristic in dermatomyositis patients with anti‐transcriptional intermediate factor 1‐γ antibody

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