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Role of the circadian system in cardiovascular disease

The Journal of clinical investigation, 2018-06, Vol.128 (6), p.2157-2167 [Peer Reviewed Journal]

COPYRIGHT 2018 American Society for Clinical Investigation ;COPYRIGHT 2018 American Society for Clinical Investigation ;Copyright American Society for Clinical Investigation Jun 2018 ;Copyright © 2018, American Society for Clinical Investigation 2018 American Society for Clinical Investigation ;ISSN: 0021-9738 ;EISSN: 1558-8238 ;DOI: 10.1172/jci80590 ;PMID: 29856365

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  • Title:
    Role of the circadian system in cardiovascular disease
  • Author: Thosar, Saurabh S ; Butler, Matthew P ; Shea, Steven A
  • Subjects: Analysis ; Autonomic nervous system ; Biological clocks ; Blood pressure ; Body temperature ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular system ; Cerebral infarction ; Circadian rhythm ; Circadian rhythms ; Diabetes ; Enzymes ; Heart attacks ; Hypertension ; Metabolism ; Myocardial infarction ; Nervous system ; Physiology ; Review ; Shift work ; Sleep
  • Is Part Of: The Journal of clinical investigation, 2018-06, Vol.128 (6), p.2157-2167
  • Description: All species organize behaviors to optimally match daily changes in the environment, leading to pronounced activity/rest cycles that track the light/dark cycle. Endogenous, approximately 24-hour circadian rhythms in the brain, autonomic nervous system, heart, and vasculature prepare the cardiovascular system for optimal function during these anticipated behavioral cycles. Cardiovascular circadian rhythms, however, may be a double-edged sword. The normal amplified responses in the morning may aid the transition from sleep to activity, but such exaggerated responses are potentially perilous in individuals susceptible to adverse cardiovascular events. Indeed, the occurrence of stroke, myocardial infarction, and sudden cardiac death all have daily patterns, striking most frequently in the morning. Furthermore, chronic disruptions of the circadian clock, as with night-shift work, contribute to increased cardiovascular risk. Here we highlight the importance of the circadian system to normal cardiovascular function and to cardiovascular disease, and identify opportunities for optimizing timing of medications in cardiovascular disease.
  • Publisher: United States: American Society for Clinical Investigation
  • Language: English
  • Identifier: ISSN: 0021-9738
    EISSN: 1558-8238
    DOI: 10.1172/jci80590
    PMID: 29856365
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
    Alma/SFX Local Collection
    ProQuest Central
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