skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Resident memory CD8 T cells persist for years in human small intestine

The Journal of experimental medicine, 2019-10, Vol.216 (10), p.2412-2426 [Peer Reviewed Journal]

2019 Bartolomé-Casado et al. ;info:eu-repo/semantics/openAccess ;2019 Bartolomé-Casado et al. 2019 ;ISSN: 0022-1007 ;EISSN: 1540-9538 ;DOI: 10.1084/jem.20190414 ;PMID: 31337737

Full text available

Citations Cited by
  • Title:
    Resident memory CD8 T cells persist for years in human small intestine
  • Author: Bartolomé-Casado, Raquel ; Landsverk, Ole J B ; Chauhan, Sudhir Kumar ; Richter, Lisa ; Phung, Danh ; Greiff, Victor ; Risnes, Louise F ; Yao, Ying ; Neumann, Ralf S ; Yaqub, Sheraz ; Øyen, Ole ; Horneland, Rune ; Aandahl, Einar Martin ; Paulsen, Vemund ; Sollid, Ludvig M ; Qiao, Shuo-Wang ; Baekkevold, Espen S ; Jahnsen, Frode L
  • Is Part Of: The Journal of experimental medicine, 2019-10, Vol.216 (10), p.2412-2426
  • Description: Resident memory CD8 T (Trm) cells have been shown to provide effective protective responses in the small intestine (SI) in mice. A better understanding of the generation and persistence of SI CD8 Trm cells in humans may have implications for intestinal immune-mediated diseases and vaccine development. Analyzing normal and transplanted human SI, we demonstrated that the majority of SI CD8 T cells were bona fide CD8 Trm cells that survived for >1 yr in the graft. Intraepithelial and lamina propria CD8 Trm cells showed a high clonal overlap and a repertoire dominated by expanded clones, conserved both spatially in the intestine and over time. Functionally, lamina propria CD8 Trm cells were potent cytokine producers, exhibiting a polyfunctional (IFN-γ IL-2 TNF-α ) profile, and efficiently expressed cytotoxic mediators after stimulation. These results suggest that SI CD8 Trm cells could be relevant targets for future oral vaccines and therapeutic strategies for gut disorders.
  • Publisher: United States: Rockefeller University Press
  • Language: English;Norwegian
  • Identifier: ISSN: 0022-1007
    EISSN: 1540-9538
    DOI: 10.1084/jem.20190414
    PMID: 31337737
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    NORA Norwegian Open Research Archives
    PubMed Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait