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Predictive validity of the quick Sequential Organ Failure Assessment

PloS one, 2022-10, Vol.17 (10), p.e0275739 [Peer Reviewed Journal]

COPYRIGHT 2022 Public Library of Science ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0275739

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  • Title:
    Predictive validity of the quick Sequential Organ Failure Assessment
  • Author: Do, Son Ngoc ; Luong, Chinh Quoc ; Nguyen, My Ha ; Pham, Dung Thi ; Nguyen, Nga Thi ; Huynh, Dai Quang ; Hoang, Quoc Trong Ai ; Dao, Co Xuan ; Vu, Thang Dinh ; Bui, Ha Nhat ; Nguyen, Hung Tan ; Hoang, Hai Bui ; Le, Thuy Thi Phuong ; Nguyen, Lien Thi Bao ; Duong, Phuoc Thien ; Nguyen, Tuan Dang ; Le, Vuong Hung ; Pham, Giang Thi Tra ; Bui, Tam Van ; Bui, Giang Thi Huong ; Phua, Jason ; Li, Andrew ; Pham, Thao Thi Ngoc ; Nguyen, Chi Van ; Nguyen, Anh Dat
  • Subjects: Analysis ; Care and treatment ; Evaluation ; Hospital patients ; Infection ; Medical research ; Medical tests ; Medicine, Experimental ; Mortality ; Patient outcomes ; Prognosis ; Sepsis ; Vietnam
  • Is Part Of: PloS one, 2022-10, Vol.17 (10), p.e0275739
  • Description: The simple scoring systems for predicting the outcome of sepsis in intensive care units (ICUs) are few, especially for limited-resource settings. Therefore, this study aimed to evaluate the accuracy of the quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score in predicting the mortality of ICU patients with sepsis in Vietnam. We did a multicenter cross-sectional study of patients with sepsis ([greater than or equal to]18 years old) presenting to 15 adult ICUs throughout Vietnam on the specified days (i.e., 9th January, 3rd April, 3rd July, and 9th October) representing the different seasons of 2019. The primary and secondary outcomes were the hospital and ICU all-cause mortalities, respectively. The area under the receiver operating characteristic curve (AUROC) was calculated to determine the discriminatory ability of the qSOFA score for deaths in the hospital and ICU. The cut-off value of the qSOFA scores was determined by the receiver operating characteristic curve analysis. Upon ICU admission, factors associated with the hospital and ICU mortalities were assessed in univariable and multivariable logistic models. Of 252 patients, 40.1% died in the hospital, and 33.3% died in the ICU. The qSOFA score had a poor discriminatory ability for both the hospital (AUROC: 0.610 [95% CI: 0.538 to 0.681]; cut-off value: [greater than or equal to]2.5; sensitivity: 34.7%; specificity: 84.1%; P.sub.AUROC = 0.003) and ICU (AUROC: 0.619 [95% CI: 0.544 to 0.694]; cutoff value: [greater than or equal to]2.5; sensitivity: 36.9%; specificity: 83.3%; P.sub.AUROC = 0.002) mortalities. However, multivariable logistic regression analyses show that the qSOFA score of 3 was independently associated with the increased risk of deaths in both the hospital (adjusted odds ratio, AOR: 3.358; 95% confidence interval, CI: 1.756 to 6.422) and the ICU (AOR: 3.060; 95% CI: 1.651 to 5.671). In our study, despite having a poor discriminatory value, the qSOFA score seems worthwhile in predicting mortality in ICU patients with sepsis in limited-resource settings.
  • Publisher: Public Library of Science
  • Language: English
  • Identifier: ISSN: 1932-6203
    EISSN: 1932-6203
    DOI: 10.1371/journal.pone.0275739
  • Source: GFMER Free Medical Journals
    PubMed Central
    Public Library of Science (PLoS)
    ProQuest Central
    DOAJ Directory of Open Access Journals
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