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The Evaluation of Cardiovascular Risk in Diabetic Patients

Acta Facultatis Pharmaceuticae Universitatis Comenianae, 2022-01, Vol.69 (1), p.1-8 [Peer Reviewed Journal]

2022. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 2453-6725 ;ISSN: 0301-2298 ;EISSN: 2453-6725 ;EISSN: 1338-6786 ;DOI: 10.2478/afpuc-2022-0001

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  • Title:
    The Evaluation of Cardiovascular Risk in Diabetic Patients
  • Author: Kosirova, S. ; Rubintova, D. ; Lacka, J. ; Klimas, J. ; Foltanova, T. ; Tumova, I.
  • Subjects: Cardiovascular disease ; coronary heart disease ; Diabetes ; gender ; stroke ; ukpds ; Women
  • Is Part Of: Acta Facultatis Pharmaceuticae Universitatis Comenianae, 2022-01, Vol.69 (1), p.1-8
  • Description: Abstract AIM The aim of the study was to evaluate cardiovascular risk in patients with diabetes mellitus type 2 according to gender. METHODS The monitoring was designed as a retrospective analysis of data obtained from the documentation of the diabetic outpatients treated with the dipeptidyl peptidase-4 inhibitors (DPP4is) or sodium–glucose co-transporter-2 (SGLT2). Cardiovascular risk was assessed according to UKPDS risk engine. RESULTS The levels of HbA1c decreased throughout the whole study. Sixty per cent of patients achieved an HbA1c level <8% after 18 months. Both men and women had similar glycaemic compensation. Men had a significantly higher risk of fatal coronary heart disease (CHD) ( p < 0.001), stroke ( p < 0.01) and fatal stroke ( p < 0.01) compared to women. We found the risk of fatal CHD to be 38-fold higher in men compared to women ( p < 0.01). CONCLUSION Potential cardiovascular effects of antidiabetic treatment should be clearly defined with possible different effects according to gender. We found a much higher risk in men than women, even when their glycaemic compensation was comparable.
  • Publisher: Bratislava: De Gruyter Poland
  • Language: English;Czech;German;Russian;Slovak
  • Identifier: ISSN: 2453-6725
    ISSN: 0301-2298
    EISSN: 2453-6725
    EISSN: 1338-6786
    DOI: 10.2478/afpuc-2022-0001
  • Source: GFMER Free Medical Journals
    Alma/SFX Local Collection
    Walter De Gruyter: Open Access Journals
    DOAJ Directory of Open Access Journals
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