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Obesity as disruptor of the female fertility

Reproductive biology and endocrinology, 2018-03, Vol.16 (1), p.22-22, Article 22 [Peer Reviewed Journal]

COPYRIGHT 2018 BioMed Central Ltd. ;The Author(s). 2018 ;ISSN: 1477-7827 ;EISSN: 1477-7827 ;DOI: 10.1186/s12958-018-0336-z ;PMID: 29523133

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  • Title:
    Obesity as disruptor of the female fertility
  • Author: Silvestris, Erica ; de Pergola, Giovanni ; Rosania, Raffaele ; Loverro, Giuseppe
  • Subjects: Adipokines ; Anovulation ; Complications and side effects ; Cytokines ; Development and progression ; Female ; Female infertility ; Genetic aspects ; Humans ; Infertility ; Infertility, Female - etiology ; Infertility, Female - metabolism ; Obesity ; Obesity - complications ; Obesity - metabolism ; Oocytes ; Physiological aspects ; Review ; Risk factors
  • Is Part Of: Reproductive biology and endocrinology, 2018-03, Vol.16 (1), p.22-22, Article 22
  • Description: Both obesity and overweight are increasing worldwide and have detrimental influences on several human body functions including the reproductive health. In particular, obese women undergo perturbations of the 'hypothalamic pituitary ovarian axis', and frequently suffer of menstrual dysfunction leading to anovulation and infertility. Besides the hormone disorders and subfertility that are common in the polycystic ovary syndrome (PCOS), in obesity the adipocytes act as endocrine organ. The adipose tissue indeed, releases a number of bioactive molecules, namely adipokines, that variably interact with multiple molecular pathways of insulin resistance, inflammation, hypertension, cardiovascular risk, coagulation, and oocyte differentiation and maturation. Moreover, endometrial implantation and other reproductive functions are affected in obese women with complications including delayed conceptions, increased miscarriage rate, reduced outcomes in assisted conception treatments.On the contrary, weight loss programs through lifestyle modification in obese women, have been proven to restore menstrual cyclicity and ovulation and improve the likelihood of conception.
  • Publisher: England: BioMed Central Ltd
  • Language: English
  • Identifier: ISSN: 1477-7827
    EISSN: 1477-7827
    DOI: 10.1186/s12958-018-0336-z
    PMID: 29523133
  • Source: Geneva Foundation Free Medical Journals at publisher websites
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