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Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis

BMJ, 2011-02, Vol.342 (7795), p.479-479 [Peer Reviewed Journal]

Ronksley et al 2011 ;2011 BMJ Publishing Group Ltd ;Copyright: 2011 © Ronksley et al 2011 ;Ronksley et al 2011 2011 Ronksley et al ;ISSN: 0959-8138 ;ISSN: 0959-8146 ;EISSN: 1468-5833 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.d671 ;PMID: 21343207 ;CODEN: BMJOAE

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Title:
Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis
Author: Ronksley, Paul E ; Brien, Susan E ; Turner, Barbara J ; Mukamal, Kenneth J ; Ghali, William A
Subjects: Alcohol drinking ; Alcohol Drinking - immunology ; Alcohol use ; Alcoholic beverages ; Alcohols ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - mortality ; Cause of Death ; Coronary artery disease ; Coronary Disease - mortality ; Data processing ; Drugs: Cardiovascular System ; Epidemiologic Studies ; Evidence-based medicine ; Health Education ; Health outcomes ; Health Promotion ; Health risk assessment ; Heart diseases ; Humans ; Incidence ; Internet ; Ischaemic Heart Disease ; Medical research ; Meta-analysis ; Mortality ; Prognosis ; Prospective Studies ; Reviews ; Risk assessment ; Risk Factors ; Stroke ; Stroke - mortality ; Strokes ; Substance abuse ; Systematic review
Is Part Of: BMJ, 2011-02, Vol.342 (7795), p.479-479
Description: Objective To conduct a comprehensive systematic review and meta-analysis of studies assessing the effect of alcohol consumption on multiple cardiovascular outcomes.Design Systematic review and meta-analysis.Data sources A search of Medline (1950 through September 2009) and Embase (1980 through September 2009) supplemented by manual searches of bibliographies and conference proceedings.Inclusion criteria Prospective cohort studies on the association between alcohol consumption and overall mortality from cardiovascular disease, incidence of and mortality from coronary heart disease, and incidence of and mortality from stroke. Studies reviewed Of 4235 studies reviewed for eligibility, quality, and data extraction, 84 were included in the final analysis.Results The pooled adjusted relative risks for alcohol drinkers relative to non-drinkers in random effects models for the outcomes of interest were 0.75 (95% confidence interval 0.70 to 0.80) for cardiovascular disease mortality (21 studies), 0.71 (0.66 to 0.77) for incident coronary heart disease (29 studies), 0.75 (0.68 to 0.81) for coronary heart disease mortality (31 studies), 0.98 (0.91 to 1.06) for incident stroke (17 studies), and 1.06 (0.91 to 1.23) for stroke mortality (10 studies). Dose-response analysis revealed that the lowest risk of coronary heart disease mortality occurred with 1–2 drinks a day, but for stroke mortality it occurred with ≤1 drink per day. Secondary analysis of mortality from all causes showed lower risk for drinkers compared with non-drinkers (relative risk 0.87 (0.83 to 0.92)).Conclusions Light to moderate alcohol consumption is associated with a reduced risk of multiple cardiovascular outcomes.
Publisher: England: British Medical Journal Publishing Group
Language: English
Identifier: ISSN: 0959-8138
ISSN: 0959-8146
EISSN: 1468-5833
EISSN: 1756-1833
DOI: 10.1136/bmj.d671
PMID: 21343207
CODEN: BMJOAE
Source: BMJ Open Access Journals
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis

Ronksley et al 2011 ;2011 BMJ Publishing Group Ltd ;Copyright: 2011 © Ronksley et al 2011 ;Ronksley et al 2011 2011 Ronksley et al ;ISSN: 0959-8138 ;ISSN: 0959-8146 ;EISSN: 1468-5833 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.d671 ;PMID: 21343207 ;CODEN: BMJOAE

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