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Stevens-Johnson syndrome/toxic epidermal necrolysis after initiation of carbamazepine in a HLA-B15:02 gene carrier – screening in risk patients is recommended

Läkartidningen, 2017-02, Vol.114 [Peer Reviewed Journal]

ISSN: 1652-7518 ;EISSN: 1652-7518 ;PMID: 28221394

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Title:
Stevens-Johnson syndrome/toxic epidermal necrolysis after initiation of carbamazepine in a HLA-B15:02 gene carrier – screening in risk patients is recommended
Author: Anastasopoulou, Stavroula ; Komuda, Magdalena ; Presman, Benjamin ; Karlsson, Maria ; Tomson, Torbjörn
Subjects: Adult ; Anticonvulsants - adverse effects ; Anticonvulsants - therapeutic use ; Asian Continental Ancestry Group - genetics ; Carbamazepine - adverse effects ; Carbamazepine - therapeutic use ; Epilepsy, Generalized - drug therapy ; Female ; HLA-B15 Antigen - genetics ; Humans ; Indonesia - ethnology ; Medicin och hälsovetenskap ; Stevens-Johnson Syndrome - etiology ; Stevens-Johnson Syndrome - genetics ; Stevens-Johnson Syndrome - pathology ; Stevens-Johnson Syndrome - therapy ; Sweden
Is Part Of: Läkartidningen, 2017-02, Vol.114
Description: Stevens-Johnson syndrome/toxic epidermal necrolysis after initiation of carbamazepine in a HLA-B*15:02 gene carrier - screening in risk patients is recommended A 32-year-old woman, adopted from Indonesia, developed Stevens-Johnsons syndrome (SJS)/toxic epidermal necrolysis (TEN) after initiating carbamazepine treatment for epilepsy. SJS and TEN are rare but life-threatening adverse effects of carbamazepine, with a 72-100% risk of occurrence in patients carrying the HLA-B*15:02 allele. The HLA-B*15:02 allele is common in several Asian groups but less prevalent in European populations. Screening for HLA-B*15:02, or choice of medication other than aromatic anticonvulsants in patients with Asian ancestry, is recommended when treatment with carbamazepine is considered.
Publisher: Sweden
Language: Swedish;English
Identifier: ISSN: 1652-7518
EISSN: 1652-7518
PMID: 28221394
Source: MEDLINE
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Stevens-Johnson syndrome/toxic epidermal necrolysis after initiation of carbamazepine in a HLA-B15:02 gene carrier – screening in risk patients is recommended

ISSN: 1652-7518 ;EISSN: 1652-7518 ;PMID: 28221394

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