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From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Cell, 2016-06, Vol.165 (6), p.1332-1345 [Peer Reviewed Journal]

2016 Elsevier Inc. ;Copyright © 2016 Elsevier Inc. All rights reserved. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2016.05.041 ;PMID: 27259147

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Title:
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Author: Koh, Ara ; De Vadder, Filipe ; Kovatcheva-Datchary, Petia ; Bäckhed, Fredrik
Subjects: Animals ; Bacteria ; Biochemistry & Molecular Biology ; Biochemistry and Molecular Biology ; Biokemi och molekylärbiologi ; butyrate-producing bacteria ; Cell and Molecular Biology ; Cell Biology ; Cell- och molekylärbiologi ; colon-cancer ; Dietary Fiber - metabolism ; Fatty Acids, Volatile - metabolism ; Gastrointestinal Microbiome - physiology ; glucagon-like ; gut microbiota ; histone deacetylases ; Histones - metabolism ; human large-intestine ; Humans ; inflammatory disease ; Intestines - immunology ; Intestines - microbiology ; nicotinic-acid ; peptide-1 ; protein-coupled receptor ; regulatory t-cells ; Signal Transduction
Is Part Of: Cell, 2016-06, Vol.165 (6), p.1332-1345
Description: A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease. A surprisingly diverse set of activities carried out by the microbial metabolites known as short-chain fatty acids may provide some of the key mechanistic links between diet, microbiota, and host physiology.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0092-8674
EISSN: 1097-4172
DOI: 10.1016/j.cell.2016.05.041
PMID: 27259147
Source: MEDLINE
Open Access: Cell Press Free Archives

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From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

2016 Elsevier Inc. ;Copyright © 2016 Elsevier Inc. All rights reserved. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2016.05.041 ;PMID: 27259147

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