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Oral zinc aspartate treats experimental autoimmune encephalomyelitis

Biometals, 2014-12, Vol.27 (6), p.1249-1262 [Peer Reviewed Journal]

Springer Science+Business Media New York 2014 ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-014-9786-8 ;PMID: 25146336

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Title:
Oral zinc aspartate treats experimental autoimmune encephalomyelitis
Author: Schubert, Claudia ; Guttek, Karina ; Grüngreiff, Kurt ; Thielitz, Anja ; Bühling, Frank ; Reinhold, Annegret ; Brocke, Stefan ; Reinhold, Dirk
Subjects: Administration, Oral ; Animals ; Arrays ; Aspartates ; Aspartic Acid - pharmacology ; Aspartic Acid - therapeutic use ; Autoimmune diseases ; Biochemistry ; Biomedical and Life Sciences ; Cell Biology ; Cells, Cultured ; Coordination Complexes - pharmacology ; Coordination Complexes - therapeutic use ; Dose-Response Relationship, Immunologic ; Drug Evaluation, Preclinical ; Encephalomyelitis, Autoimmune, Experimental - blood ; Encephalomyelitis, Autoimmune, Experimental - drug therapy ; Female ; Homeostasis ; Human ; Humans ; Immune system ; In vitro testing ; Life Sciences ; Lymphocyte Activation ; Lymphokines - secretion ; Medicine/Public Health ; Mice ; Mice, Inbred Strains ; Microbiology ; Multiple sclerosis ; Pharmacology/Toxicology ; Plant Physiology ; Spleen - cytology ; T-Lymphocytes - drug effects ; T-Lymphocytes - secretion ; Trace elements ; Zinc ; Zinc - blood
Is Part Of: Biometals, 2014-12, Vol.27 (6), p.1249-1262
Description: The essential trace element zinc plays a critical role in the regulation of immune homeostasis. Zinc deficiency or excess can cause severe impairment of the immune response, which points to the importance of the physiological and dietary control of zinc levels for a functioning immune system. We previously reported that injection of zinc aspartate suppresses experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), as well as effector T cell functions in vitro. Among the preferred characteristics of novel therapeutics for the treatment of autoimmune diseases such as MS are oral availability and a tolerable effective dose to minimize side effects. In this study, we investigated whether oral administration of zinc aspartate, an approved drug to treat zinc deficiency in humans, is effective in controlling EAE at clinically approved doses. We show that oral administration of 6 µg/day [0.3 mg/kg body weight (BW)] or 12 µg/day [0.6 mg/kg BW] of zinc aspartate reduces clinical and histopathological signs during the relapsing remitting phase of the disease in SJL mice. The clinical effect in mice was accompanied by suppression of IFN-γ, TNF-α, GM-CSF and IL-5 production in stimulated human T cells and mouse splenocytes in a dose-dependent manner. Furthermore, a large array of proinflammatory cytokines was modulated by zinc aspartate exposure in vitro. These data suggest that administration of oral zinc aspartate may have beneficial effects on autoimmune diseases like MS.
Publisher: Dordrecht: Springer Netherlands
Language: English;Dutch
Identifier: ISSN: 0966-0844
EISSN: 1572-8773
DOI: 10.1007/s10534-014-9786-8
PMID: 25146336
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Oral zinc aspartate treats experimental autoimmune encephalomyelitis

Springer Science+Business Media New York 2014 ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-014-9786-8 ;PMID: 25146336

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