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Correlation of Blood Urea and Creatinine Levels With Thiamin Levels in Type 1 and Type 2 Diabetic Patients

Curēus (Palo Alto, CA), 2024-03, Vol.16 (3), p.e57022-e57022 [Peer Reviewed Journal]

Copyright © 2024, Anwar et al. ;Copyright © 2024, Anwar et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 2168-8184 ;EISSN: 2168-8184 ;DOI: 10.7759/cureus.57022 ;PMID: 38681462

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  • Title:
    Correlation of Blood Urea and Creatinine Levels With Thiamin Levels in Type 1 and Type 2 Diabetic Patients
  • Author: Anwar, Adnan ; Faisal, Fizza ; Elahi, Wajeeha ; Illahi, Ahsan ; Alam, Syed Munawar ; Adnan, Syed Tariq Ali ; Batool, Syed Asra ; Bhagwandas, Sania ; Hashmi, Atif A
  • Subjects: Biomarkers ; Blood pressure ; Cardiovascular disease ; Coronary vessels ; Creatinine ; Demographics ; Diabetes ; Diabetic nephropathy ; Diuretics ; Gender ; Hypertension ; Insulin ; Kidneys ; Males ; Metabolism ; Vein & artery diseases ; Vitamin B
  • Is Part Of: Curēus (Palo Alto, CA), 2024-03, Vol.16 (3), p.e57022-e57022
  • Description: Introduction Serum urea and creatinine levels are the most commonly recognized parameters for evaluating renal impairment in patients with diabetes mellitus (DM). Therefore, this study evaluated the correlation between urea and creatinine levels and thiamin levels in patients with type 1 DM (T1DM) and type 2 DM (T2DM). Methods This multi-center, cross-sectional study was conducted at diabetic outpatient clinics in Karachi. The duration of the study was six months, from 1 January 2023 to 30 June 2023. A total of 60 patients were enrolled and divided into two groups, i.e., T1DM and T2DM, each containing 30 patients of both genders between the ages of 24 and 42 years. Demographic data and biochemical variables, such as urea, creatinine, random blood sugar, fasting blood sugar, hemoglobin A1c, and serum thiamin levels, were assessed. The Mann-Whitney U test and independent t-test were used to associate the means between the two study groups. The chi-square test and Spearman's correlation coefficient were used to determine the associations between the variables and T1DM and T2DM. Results The study results revealed that patients with T2DM had a significantly higher frequency of hypertension (p = 0.039), neuropathy (p = 0.038), and coronary artery disease (p = 0.010) than those with T1DM, in both genders. The level of serum thiamin was found to be significantly higher (p < 0.001) in T2DM (14.8 ± 4.82) than in T1DM patients (7.34 ± 1.90). Similarly, serum creatinine was higher in T2DM than in T1DM patients (0.83 ± 0.12 vs. 0.76 ± 0.17, p = 0.025). Moreover, the correlation of urea and creatinine with thiamin levels in T1DM and T2DM patients revealed that in T1DM and T2DM patients, urea and creatinine showed an insignificant positive correlation with thiamin levels. Conclusion We found a significantly higher level of serum creatinine and thiamin levels in T2DM patients than in T1DM; however, there was no significant correlation between urea and creatinine levels and thiamin status in T1DM and T2DM patients. Therefore, we conclude that although serum urea, creatinine, and serum thiamin are important disease biomarkers in diabetic patients, there is no correlation between them.
  • Publisher: United States: Cureus Inc
  • Language: English
  • Identifier: ISSN: 2168-8184
    EISSN: 2168-8184
    DOI: 10.7759/cureus.57022
    PMID: 38681462
  • Source: PubMed Central
    ProQuest Central
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