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Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS

International Journal of Obesity, 2019-07, Vol.43 (7), p.1370-1379 [Peer Reviewed Journal]

This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2019 ;ISSN: 0307-0565 ;EISSN: 1476-5497 ;DOI: 10.1038/s41366-019-0318-z ;PMID: 30718819

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Title:
Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS
Author: Koivuaho, E ; Laru, J ; Ojaniemi, M ; Puukka, K ; Kettunen, J ; Tapanainen, J S ; Franks, S ; Järvelin, M-R ; Morin-Papunen, L ; Sebert, S ; Piltonen, T T
Subjects: Adipose tissue ; Adiposity - physiology ; Adolescent ; Adolescents ; Adult ; Age ; Birth weight ; Body mass ; Body Mass Index ; Child ; Child, Preschool ; Children ; Correlation analysis ; Diagnosis ; Female ; Finland - epidemiology ; Girls ; Growth patterns ; Hirsutism ; Humans ; Infant ; Infant, Newborn ; Longitudinal Studies ; Menarche ; Metabolism ; Middle Aged ; Obesity ; Obesity - complications ; Obesity - physiopathology ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - epidemiology ; Polycystic Ovary Syndrome - etiology ; Polycystic Ovary Syndrome - physiopathology ; Population studies ; Prevalence ; Prospective Studies ; Signs and symptoms ; Weight ; Young Adult
Is Part Of: International Journal of Obesity, 2019-07, Vol.43 (7), p.1370-1379
Description: Adiposity rebound (AR), the second BMI rise in childhood at around the age of 6 years, is associated with obesity and metabolic alteration in later life. Given that polycystic ovary syndrome (PCOS) has a strong metabolic component, early life growth patterns could reveal a risk of PCOS. Thus, we aimed to investigate the associations between age at AR and PCOS diagnosis and BMI later in life. This study is part of a prospective, population-based longitudinal study, where women with PCOS diagnosis by age 46 (n = 280) were compared with asymptomatic women (CTRLs, n = 1573). Weight and height data from birth to age 13 years, at age at menarche, and at ages 31 and 46 years were analyzed RESULTS: Women with PCOS had lower birth weight (3357 ± 477 vs. 3 445 ± 505 g, p < 0.001), earlier age at AR (5.2 ± 1.0 vs. 5.6 ± 0.90 years, p < 0.001) and higher BMI from AR onwards compared with controls. Early timing of AR was associated with PCOS diagnosis independently of BMI (OR 1.62, 95% Cl 1.37-1.92). Women with PCOS and early AR had higher BMI at 31 and 46 years when compared to controls with early AR. The age at AR did not associate with T levels at ages 31 or 46 years. Early AR was associated with PCOS diagnosis and high BMI in adulthood. Adolescent girls with early AR and persisting obesity should be screened for PCOS symptoms, such as persistent irregular cycles and hirsutism.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0307-0565
EISSN: 1476-5497
DOI: 10.1038/s41366-019-0318-z
PMID: 30718819
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS

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