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Clock-driven vasopressin neurotransmission mediates anticipatory thirst prior to sleep

Nature (London), 2016-09, Vol.537 (7622), p.685-688 [Tạp chí có phản biện]

COPYRIGHT 2016 Nature Publishing Group ;COPYRIGHT 2016 Nature Publishing Group ;Copyright Nature Publishing Group Sep 29, 2016 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature19756 ;PMID: 27680940 ;CODEN: NATUAS

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Nhan đề:
Clock-driven vasopressin neurotransmission mediates anticipatory thirst prior to sleep
Tác giả: Gizowski, C ; Zaelzer, C ; Bourque, C W
Chủ đề: Animal behavior ; Animals ; Anticipation, Psychological ; Biological Clocks - physiology ; Circadian rhythm ; Dehydration ; Drinking - physiology ; Female ; Health aspects ; Male ; Mice ; Neural transmission ; Observations ; Optogenetics ; Organum Vasculosum - cytology ; Organum Vasculosum - metabolism ; Organum Vasculosum - secretion ; Physiology ; Post-Synaptic Density - metabolism ; Receptors, Vasopressin - metabolism ; Rodents ; Sleep ; Sleep - physiology ; Studies ; Synaptic Transmission ; Thirst - physiology ; Vasopressin ; Vasopressins ; Vasopressins - metabolism ; Vasopressins - secretion ; Water-Electrolyte Balance
Là 1 phần của: Nature (London), 2016-09, Vol.537 (7622), p.685-688
Mô tả: Circadian rhythms have evolved to anticipate and adapt animals to the constraints of the earth's 24-hour light cycle. Although the molecular processes that establish periodicity in clock neurons of the suprachiasmatic nucleus (SCN) are well understood, the mechanisms by which axonal projections from the central clock drive behavioural rhythms are unknown. Here we show that the sleep period in mice (Zeitgeber time, ZT0-12) is preceded by an increase in water intake promoted entirely by the central clock, and not motivated by physiological need. Mice denied this surge experienced significant dehydration near the end of the sleep period, indicating that this water intake contributes to the maintenance of overnight hydromineral balance. Furthermore, this effect relies specifically on the activity of SCN vasopressin (VP) neurons that project to thirst neurons in the OVLT (organum vasculosum lamina terminalis), where VP is released as a neurotransmitter. SCN VP neurons become electrically active during the anticipatory period (ZT21.5-23.5), and depolarize and excite OVLT neurons through the activation of postsynaptic VP V1a receptors and downstream non-selective cation channels. Optogenetic induction of VP release before the anticipatory period (basal period; ZT19.5-21.5) excited OVLT neurons and prompted a surge in water intake. Conversely, optogenetic inhibition of VP release during the anticipatory period inhibited the firing of OVLT neurons and prevented the corresponding increase in water intake. Our findings reveal the existence of anticipatory thirst, and demonstrate this behaviour to be driven by excitatory peptidergic neurotransmission mediated by VP release from central clock neurons.
Nơi xuất bản: England: Nature Publishing Group
Ngôn ngữ: English
Số nhận dạng: ISSN: 0028-0836
EISSN: 1476-4687
DOI: 10.1038/nature19756
PMID: 27680940
CODEN: NATUAS
Nguồn: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
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Clock-driven vasopressin neurotransmission mediates anticipatory thirst prior to sleep

COPYRIGHT 2016 Nature Publishing Group ;COPYRIGHT 2016 Nature Publishing Group ;Copyright Nature Publishing Group Sep 29, 2016 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature19756 ;PMID: 27680940 ;CODEN: NATUAS

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