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Biomarkers for infection in children: current clinical practice and future perspectives
2019 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. ;ISSN: 0891-3668 ;EISSN: 1532-0987 ;DOI: 10.1097/INF.0000000000002318
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Title:
Biomarkers for infection in children: current clinical practice and future perspectives
Author:
Stol, K
;
Nijman, RG
;
Van Herk, W
;
Van Rossum, AMC
Subjects:
1114 Paediatrics and Reproductive Medicine
;
1117 Public Health and Health Services
;
Age Factors
;
Algorithms
;
biomarker
;
Biomarkers
;
C-reactive protein
;
Child
;
Child, Preschool
;
Diagnostic Tests, Routine
;
Disease Management
;
Disease Susceptibility
;
EARLY-ONSET SEPSIS
;
EMERGENCY-DEPARTMENT
;
FEBRILE CHILDREN
;
FEVER
;
Host-Pathogen Interactions
;
Humans
;
Immunology
;
Infections
;
Infectious Diseases
;
Life Sciences & Biomedicine
;
NEUTROPHIL CD64 EXPRESSION
;
Pediatrics
;
procalcitonin
;
PROCALCITONIN CONCENTRATIONS
;
Reproducibility of Results
;
Science & Technology
;
SENSITIVE DIAGNOSTIC MARKER
;
Sensitivity and Specificity
;
SERIOUS BACTERIAL-INFECTIONS
;
serious blood stream infection
;
VIRAL-INFECTION
Description:
Biomarkers have become an integral part of the clinical decision-making process of clinicians dealing with febrile children. C-reactive protein, procalcitonin and white blood cell count are probably the most studied ones. Crucial to using biomarkers is the understanding of how a test result will alter post-test probabilities and then impact on clinical decision making. Improved analytical and computational platforms have enabled the next generation of advanced biomarker discovery studies. Promising combinations of candidate biomarkers for a diverse spectrum of febrile illnesses, such as viral and bacterial infections, have been identified using proteomics, RNA gene expression and metabolomics.
Publisher:
Lippincott, Williams & Wilkins
Creation Date:
2019-02
Language:
English
Identifier:
ISSN: 0891-3668
EISSN: 1532-0987
DOI: 10.1097/INF.0000000000002318
Source:
Spiral
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