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Pulmonary disease caused by a newly identified mycobacterium: Mycolicibacterium toneyamachuris: a case report

BMC infectious diseases, 2020-11, Vol.20 (1), p.888-888, Article 888 [Peer Reviewed Journal]

COPYRIGHT 2020 BioMed Central Ltd. ;COPYRIGHT 2020 BioMed Central Ltd. ;2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020 ;ISSN: 1471-2334 ;EISSN: 1471-2334 ;DOI: 10.1186/s12879-020-05626-y ;PMID: 33238934

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Title:
Pulmonary disease caused by a newly identified mycobacterium: Mycolicibacterium toneyamachuris: a case report
Author: Kuge, Tomoki ; Fukushima, Kiyoharu ; Matsumoto, Yuki ; Abe, Yuko ; Akiba, Eri ; Haduki, Kako ; Saito, Haruko ; Nitta, Tadayoshi ; Kawano, Akira ; Kawasaki, Takahiro ; Matsuki, Takanori ; Kagawa, Hiroyuki ; Motooka, Daisuke ; Tsujino, Kazuyuki ; Miki, Mari ; Miki, Keisuke ; Kitada, Seigo ; Nakamura, Shota ; Iida, Tetsuya ; Kida, Hiroshi
Subjects: Adult ; Amikacin ; Analysis ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antibacterial agents ; Bacterial infections ; Care and treatment ; Case Report ; Case reports ; Clarithromycin ; Computed tomography ; Deoxyribonucleic acid ; Diagnosis ; Diagnostic Tests, Routine ; DNA ; Female ; Genomes ; Genomics ; Humans ; Identification and classification ; Imipenem ; Infections ; Infectious diseases ; Leprosy ; Lung diseases ; Lung Diseases - diagnosis ; Lung Diseases - microbiology ; Medical colleges ; Medical research ; Medicine, Experimental ; Microbial Sensitivity Tests ; Moxifloxacin ; Multilocus Sequence Typing - methods ; Mycobacteria ; Mycobacterial infections ; Mycobacterium ; Mycobacterium Infections, Nontuberculous - diagnosis ; Mycobacterium Infections, Nontuberculous - drug therapy ; Mycobacterium Infections, Nontuberculous - microbiology ; Nontuberculous Mycobacteria - drug effects ; Nontuberculous Mycobacteria - genetics ; Nontuberculous Mycobacteria - isolation & purification ; Patient outcomes ; Phylogenetics ; Proteins ; Sensitivity ; Sensitivity analysis ; Signs and symptoms ; Species classification ; Tetracycline ; Tetracyclines ; Treatment Outcome ; Tuberculosis ; Whole Genome Sequencing - methods
Is Part Of: BMC infectious diseases, 2020-11, Vol.20 (1), p.888-888, Article 888
Description: Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is becoming a significant health burden. Recent advances in analysis techniques have allowed the accurate identification of previously unknown NTM species. Here, we report a case of NTM-PD caused by a newly identified mycobacteria in an immunocompetent patient. A 44-year-old woman was referred to our hospital due to the frequent aggravation of her chronic respiratory symptoms, with NTM-PD-compatible computed tomography findings. Unidentified mycobacterium was repeatedly isolated from respiratory specimens and we diagnosed her as NTM-PD of unidentified mycobacterium. Subsequent whole-genome analysis revealed that the unidentified mycobacterium was a novel mycobacterium genetically close to Mycolicibacterium mucogenicum. We started combination therapy with clarithromycin, moxifloxacin, amikacin, and imipenem/cilastatin, referring to drug sensitivity test results and observed its effect on M. mucogenicum infection. Her symptoms and radiological findings improved significantly. We report a case of NTM-PD caused by a newly identified mycobacteria, Mycolicibacterium toneyamachuris, genetically close to M. mucogenicum. This pathogenic mycobacterium showed different characteristics from M. mucogenicum about clinical presentation and drug sensitivity. The clinical application of genomic sequencing will advance the identification and classification of pathogenic NTM species, and enhance our understanding of mycobacterial diseases.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1471-2334
EISSN: 1471-2334
DOI: 10.1186/s12879-020-05626-y
PMID: 33238934
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Springer Nature OA/Free Journals
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Pulmonary disease caused by a newly identified mycobacterium: Mycolicibacterium toneyamachuris: a case report

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