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P105 Does the extent of pleural involvement by malignancy affect pleurodesis outcome in patients with pleural effusion? A systematic review

Thorax, 2019-12, Vol.74 (Suppl 2), p.A147 [Peer Reviewed Journal]

Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. ;2019 Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. ;ISSN: 0040-6376 ;EISSN: 1468-3296 ;DOI: 10.1136/thorax-2019-BTSabstracts2019.248

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  • Title:
    P105 Does the extent of pleural involvement by malignancy affect pleurodesis outcome in patients with pleural effusion? A systematic review
  • Author: Hassan, M ; Gadallah, M ; Harriss, E ; Corcoran, JP ; Rahman, NM
  • Subjects: Systematic review
  • Is Part Of: Thorax, 2019-12, Vol.74 (Suppl 2), p.A147
  • Description: BackgroundThe British Thoracic Society Pleural guidelines recommend attempting pleurodesis in patients with malignant pleural effusion (MPE) whose chest X-rays show evidence of less than 50% lung entrapment,1 suggesting that more extensive entrapment would predict pleurodesis failure. It is not clear, however, how far the extent of pleural involvement by malignancy affects pleurodesis outcome.MethodsA systematic review of papers available on PubMed, Embase and Cochrane databases published in English on the subject of pleurodesis was carried out(protocol CRD42018115874). Only papers with clear definition of pleurodesis success with 20 or more patients were included.ResultsThe search returned 972 titles. Six papers (reporting on 1155 patients) studying MPE due to different primaries contained data on the relation between tumour burden assessed during thoracoscopic examination of the pleural cavity. Five of the included papers utilised a score developed previously.2Table 1 summarises the included studies and the effect measures reported. There was no uniform way of interpreting the results of the pleural burden score.ConclusionOnly papers of retrospective design linked higher pleural tumour burden with pleurodesis failure. More robust evidence is required from prospectively designed studies.ReferencesRoberts, et al. Thorax 2010;65:ii32–40.Sanchez-Armengol A, et al. Chest 1993;104:1482–5.Abstract P105 Table 1
  • Publisher: London: BMJ Publishing Group LTD
  • Language: English
  • Identifier: ISSN: 0040-6376
    EISSN: 1468-3296
    DOI: 10.1136/thorax-2019-BTSabstracts2019.248
  • Source: Alma/SFX Local Collection
    ProQuest Central
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