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Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease

Nature medicine, 2019-11, Vol.25 (11), p.1753-1760 [Tạp chí có phản biện]

COPYRIGHT 2019 Nature Publishing Group ;COPYRIGHT 2019 Nature Publishing Group ;The Author(s), under exclusive licence to Springer Nature America, Inc. 2019. ;ISSN: 1078-8956 ;EISSN: 1546-170X ;DOI: 10.1038/s41591-019-0627-8 ;PMID: 31700174

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Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease
Tác giả: Lees, Jennifer S ; Welsh, Claire E ; Celis-Morales, Carlos A ; Mackay, Daniel ; Lewsey, James ; Gray, Stuart R ; Lyall, Donald M ; Cleland, John G ; Gill, Jason M R ; Jhund, Pardeep S ; Pell, Jill ; Sattar, Naveed ; Welsh, Paul ; Mark, Patrick B
Chủ đề: Adult ; Aged ; Albuminuria - complications ; Albuminuria - diagnosis ; Albuminuria - physiopathology ; Albuminuria - urine ; Arteriosclerosis ; Atherosclerosis ; Biological Specimen Banks ; Biomarkers - blood ; Biomarkers - urine ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - physiopathology ; Care and treatment ; Creatinine ; Creatinine - metabolism ; Cystatin C ; End-stage renal disease ; Epidermal growth factor receptors ; Female ; Glomerular filtration rate ; Glomerular Filtration Rate - physiology ; Health risk assessment ; Health risks ; Heart diseases ; Humans ; Kidney diseases ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - diagnosis ; Kidney Failure, Chronic - physiopathology ; Kidneys ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Mortality ; Prediction models ; Prevention ; Reclassification ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - physiopathology ; Risk analysis ; Risk assessment ; Risk Factors
Là 1 phần của: Nature medicine, 2019-11, Vol.25 (11), p.1753-1760
Mô tả: Chronic kidney disease is common in the general population and associated with excess cardiovascular disease (CVD), but kidney function does not feature in current CVD risk-prediction models. We tested three formulae for estimated glomerular filtration rate (eGFR) to determine which was the most clinically informative for predicting CVD and mortality. Using data from 440,526 participants from UK Biobank, eGFR was calculated using serum creatinine, cystatin C (eGFRcys) and creatinine-cystatin C. Associations of each eGFR with CVD outcome and mortality were compared using Cox models and adjusting for atherosclerotic risk factors (per relevant risk scores), and the predictive utility was determined by the C-statistic and categorical net reclassification index. We show that eGFRcys is most strongly associated with CVD and mortality, and, along with albuminuria, adds predictive discrimination to current CVD risk scores, whilst traditional creatinine-based measures are weakly associated with risk. Clinicians should consider measuring eGFRcys as part of cardiovascular risk assessment.
Nơi xuất bản: United States: Nature Publishing Group
Ngôn ngữ: English
Số nhận dạng: ISSN: 1078-8956
EISSN: 1546-170X
DOI: 10.1038/s41591-019-0627-8
PMID: 31700174
Nguồn: MEDLINE
ProQuest Central

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Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease

COPYRIGHT 2019 Nature Publishing Group ;COPYRIGHT 2019 Nature Publishing Group ;The Author(s), under exclusive licence to Springer Nature America, Inc. 2019. ;ISSN: 1078-8956 ;EISSN: 1546-170X ;DOI: 10.1038/s41591-019-0627-8 ;PMID: 31700174

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