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Researching COVID to Enhance Recovery
PloS one, 2023-06, Vol.18 (6), p.e0286297
[Peer Reviewed Journal]
COPYRIGHT 2023 Public Library of Science ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0286297
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Title:
Researching COVID to Enhance Recovery
Author:
Thaweethai, Tanayott
;
Brosnahan, Shari B
;
Cicek, Mine S
;
Goldman, Jason D
;
Hess, Rachel
;
Hodder, S. L
;
Laiyemo, Adeyinka O
;
Metz, Torri D
;
Patzer, Rachel E
;
Sekar, Anisha
;
Stiles, Lauren E
;
Taylor, Barbara S
;
Ahmed, Shifa
;
Algren, Heather A
;
Ashktorab, Hassan
;
Bedi, Brahmchetna
;
Bhadelia, Nahid
;
Bind, Marie-Abele C
;
Black, Lora J
;
Brim, Hassan
;
Chen, Benjamin K
;
Chen, Peter
;
Chibnik, Lori B
;
Costantine, Maged M
;
Cribbs, Sushma K
;
Deeks, Steven G
;
Durstenfeld, Matthew S
;
Emery, Ivette F
;
Erlandson, Kristine M
;
Facelli, Julio C
;
Farah-Abraham, Rachael
;
Fleurimont, Judes
;
Gallagher, Emily J
;
Gander, Jennifer C
;
Gibson, Kelly S
;
Granger, Joey P
;
Greenway, Frank L
;
Hafner, John W
;
Hoffman, Matthew K
;
Hsue, Priscilla Y
;
James, Judith A
;
John, Janice
;
Jolley, Sarah
;
Judd, S. E
;
Juskowich, Joy J
;
Kanjilal, Diane G
;
Kelly, J. Daniel
;
Kim, Arthur Y
;
Knox, Kenneth S
;
Lanca, Margaret
;
Levy, Bruce D
;
Logarbo, Brian P
;
Logue, Jennifer K
;
Longo, Michele T
;
Malakooti, Shahdi K
;
Mallett, Gail
;
Marconi, Vincent C
;
Marshall, Gailen D
;
Martin, Christopher F
;
McComsey, Grace A
;
McDonald, Dylan
;
Miele, Lucio
;
Neuman, Robert B
;
Nguyen, Amber
;
Ofotokun, Igho
;
Palatnik, Anna
;
Parry, Samuel
;
Patterson, Thomas F
;
Pearman, Ann
;
Peluso, Michael J
;
Pemu, Priscilla
;
Pettker, Christian M
;
Plunkett, Beth A
;
Pogreba-Brown, Kristen
;
Poppas, Athena
;
Quinn, Davin K
;
Raissy, Hengameh
;
Rebello, Candida J
;
Reddy, Uma M
;
Rouse, Dwight J
;
Ruff, Adam M
;
Saint Jean, Christina
;
Sandoval, Grecio J
;
Schlater, Shannon M
;
Sciurba, Frank C
;
Seshadri, Sudha
;
Shemesh, Eyal
;
Simhan, Hyagriv N
;
Sowles, Amber
;
Tuttle, Katherine R
;
Utz, P. J
;
Vernon, Suzanne D
;
Weeks, Ryan M
;
Wheeler, Jennifer L
;
Whiteheart, Sidney W
;
Wiley, Zanthia
;
Williams, Natasha J
;
Wisnivesky, Juan P
;
Zisis, Sokratis N
;
Foulkes, Andrea S
Subjects:
Adults
;
Epidemics
;
Health aspects
;
Medical research
;
Medicine, Experimental
;
Observational studies
Is Part Of:
PloS one, 2023-06, Vol.18 (6), p.e0286297
Description:
Importance RECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged [greater than or equal to]18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility- and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross-validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms. RECOVER-Adult is the first national, prospective, longitudinal cohort of PASC among US adults. Results of this study are intended to inform public health, spur clinical trials, and expand treatment options.
Publisher:
Public Library of Science
Language:
English
Identifier:
ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0286297
Source:
Geneva Foundation Free Medical Journals at publisher websites
PubMed Central
Public Library of Science
ProQuest Central
DOAJ Directory of Open Access Journals
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