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Childhood Adversities Increase the Risk of Psychosis: A Meta-analysis of Patient-Control, Prospective- and Cross-sectional Cohort Studies

Schizophrenia bulletin, 2012-06, Vol.38 (4), p.661-671 [Tạp chí có phản biện]

2015 INIST-CNRS ;The Authors 2012. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. 2012 ;ISSN: 0586-7614 ;EISSN: 1745-1701 ;DOI: 10.1093/schbul/sbs050 ;PMID: 22461484 ;CODEN: SCZBB3

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Nhan đề:
Childhood Adversities Increase the Risk of Psychosis: A Meta-analysis of Patient-Control, Prospective- and Cross-sectional Cohort Studies
Tác giả: VARESE, Filippo ; SMEETS, Feikje ; DRUKKER, Marjan ; LIEVERSE, Ritsaert ; LATASTER, Tineke ; VIECHTBAUER, Wolfgang ; READ, John ; VAN OS, Jim ; BENTALL, Richard P
Chủ đề: Adolescent ; Adult ; Adult and adolescent clinical studies ; Adult Survivors of Child Abuse - psychology ; Adult Survivors of Child Abuse - statistics & numerical data ; Biological and medical sciences ; Bullying - psychology ; Case-Control Studies ; Child ; Child Abuse - psychology ; Child Abuse - statistics & numerical data ; Cohort Studies ; Cross-Sectional Studies ; Humans ; Medical sciences ; Parental Death - psychology ; Parental Death - statistics & numerical data ; Prospective Studies ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Psychotic Disorders - epidemiology ; Psychotic Disorders - etiology ; Risk Factors ; Schizophrenia
Là 1 phần của: Schizophrenia bulletin, 2012-06, Vol.38 (4), p.661-671
Mô tả: Evidence suggests that adverse experiences in childhood are associated with psychosis. To examine the association between childhood adversity and trauma (sexual abuse, physical abuse, emotional/psychological abuse, neglect, parental death, and bullying) and psychosis outcome, MEDLINE, EMBASE, PsychINFO, and Web of Science were searched from January 1980 through November 2011. We included prospective cohort studies, large-scale cross-sectional studies investigating the association between childhood adversity and psychotic symptoms or illness, case-control studies comparing the prevalence of adverse events between psychotic patients and controls using dichotomous or continuous measures, and case-control studies comparing the prevalence of psychotic symptoms between exposed and nonexposed subjects using dichotomous or continuous measures of adversity and psychosis. The analysis included 18 case-control studies (n = 2048 psychotic patients and 1856 nonpsychiatric controls), 10 prospective and quasi-prospective studies (n = 41,803) and 8 population-based cross-sectional studies (n = 35,546). There were significant associations between adversity and psychosis across all research designs, with an overall effect of OR = 2.78 (95% CI = 2.34-3.31). The integration of the case-control studies indicated that patients with psychosis were 2.72 times more likely to have been exposed to childhood adversity than controls (95% CI = 1.90-3.88). The association between childhood adversity and psychosis was also significant in population-based cross-sectional studies (OR = 2.99 [95% CI = 2.12-4.20]) as well as in prospective and quasi-prospective studies (OR = 2.75 [95% CI = 2.17-3.47]). The estimated population attributable risk was 33% (16%-47%). These findings indicate that childhood adversity is strongly associated with increased risk for psychosis.
Nơi xuất bản: Oxford: Oxford University Press
Ngôn ngữ: English
Số nhận dạng: ISSN: 0586-7614
EISSN: 1745-1701
DOI: 10.1093/schbul/sbs050
PMID: 22461484
CODEN: SCZBB3
Nguồn: Open Access: PubMed Central
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
Alma/SFX Local Collection

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Childhood Adversities Increase the Risk of Psychosis: A Meta-analysis of Patient-Control, Prospective- and Cross-sectional Cohort Studies

2015 INIST-CNRS ;The Authors 2012. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. 2012 ;ISSN: 0586-7614 ;EISSN: 1745-1701 ;DOI: 10.1093/schbul/sbs050 ;PMID: 22461484 ;CODEN: SCZBB3

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