skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis

BMJ (Online), 2017-01, Vol.356, p.j138-j138 [Peer Reviewed Journal]

Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. ;Copyright: 2017 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to 2017 BMJ ;ISSN: 0959-8138 ;ISSN: 1756-1833 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.j138 ;PMID: 28143834

Full text available

Citations Cited by
  • Title:
    Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis
  • Author: Wang, Rui ; Kim, Bobae V ; van Wely, Madelon ; Johnson, Neil P ; Costello, Michael F ; Zhang, Hanwang ; Ng, Ernest Hung Yu ; Legro, Richard S ; Bhattacharya, Siladitya ; Norman, Robert J ; Mol, Ben Willem J
  • Subjects: Anovulation - drug therapy ; Anovulation - physiopathology ; Clomiphene - therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Infertility, Female - drug therapy ; Infertility, Female - physiopathology ; Letrozole ; Metformin - therapeutic use ; Network Meta-Analysis ; Nitriles - therapeutic use ; Ovulation Induction - methods ; Pregnancy ; Pregnancy Rate ; Treatment Outcome ; Triazoles - therapeutic use
  • Is Part Of: BMJ (Online), 2017-01, Vol.356, p.j138-j138
  • Description: AbstractObjectiveTo compare the effectiveness of alternative first line treatment options for women with WHO group II anovulation wishing to conceive.DesignSystematic review and network meta-analysis.Data sourcesCochrane Central Register of Controlled Trials, Medline, and Embase, up to 11 April 2016.Study selectionRandomised controlled trials comparing eight ovulation induction treatments in women with WHO group II anovulation: clomiphene, letrozole, metformin, clomiphene and metformin combined, tamoxifen, gonadotropins, laparoscopic ovarian drilling, and placebo or no treatment. Study quality was measured on the basis of the methodology and categories described in the Cochrane Collaboration Handbook. Pregnancy, defined preferably as clinical pregnancy, was the primary outcome; live birth, ovulation, miscarriage, and multiple pregnancy were secondary outcomes.ResultsOf 2631 titles and abstracts initially identified, 54 trials reporting on 7173 women were included. All pharmacological treatments were superior to placebo or no intervention in terms of pregnancy and ovulation. Compared with clomiphene alone, both letrozole and the combination of clomiphene and metformin showed higher pregnancy rates (odds ratio 1.69, 95% confidence interval 1.33 to 2.14; 1.71, 1.28 to 2.27; respectively). Letrozole led to higher live birth rates when compared with clomiphene alone (1.67, 1.11 to 2.49). Metformin led to lower multiple pregnancy rates compared with clomiphene alone (0.22, 0.05 to 0.93).ConclusionsIn women with WHO group II anovulation, letrozole and the combination of clomiphene and metformin are superior to clomiphene alone in terms of pregnancy. Compared with clomiphene alone, letrozole is the only treatment showing a significantly higher rate of live birth.Systematic review registrationPROSPERO CRD42015027579.Readers’ noteThis is the second version of this paper. The original version was corrected following the retraction of two studies and removal of another which were ineligible (references 40, 41, and 75 of the original paper). These studies are not shown in this version. A tracked changes version of the original version is attached as a supplementary file to the correction notice, which explains the issue further.
  • Publisher: England: British Medical Journal Publishing Group
  • Language: English
  • Identifier: ISSN: 0959-8138
    ISSN: 1756-1833
    EISSN: 1756-1833
    DOI: 10.1136/bmj.j138
    PMID: 28143834
  • Source: BMJ Open Access Journals
    MEDLINE
    ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait