skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Amiodarone pulmonary toxicity: case report

Srpski arhiv za celokupno lekarstvo, 2014-07, Vol.142 (7-8), p.480-483

ISSN: 0370-8179 ;EISSN: 2406-0895 ;DOI: 10.2298/SARH1408480V ;PMID: 25233696

Full text available

Citations Cited by
  • Title:
    Amiodarone pulmonary toxicity: case report
  • Author: Vasić, Nada ; Pesut, Dragica ; Stević, Ruza ; Jovanović, Dragana ; Radivojević, Slavisa
  • Subjects: Aged ; amiodarone ; Amiodarone - toxicity ; Anti-Arrhythmia Agents - toxicity ; atrial fibrillation ; Cryptogenic Organizing Pneumonia - chemically induced ; diagnosis ; Humans ; lung function ; lungs ; Male ; toxicity
  • Is Part Of: Srpski arhiv za celokupno lekarstvo, 2014-07, Vol.142 (7-8), p.480-483
  • Description: Amiodarone, an antiarrhythmic drug, which contains iodine compound, has a tendency to accumulate in some organs including the lungs.This is age, drug dosage and therapy duration dependent. We present a case of a 73-year-old man, a smoker, who was admitted as emergency case due to severe dyspnea, tachypnea with signs of cyanosis and respiratory insufficiency. Chest x-ray revealed bilateral diffuse pulmonary shadows in the middle and upper parts of the lungs, similar to those in tuberculosis. His illness history showed chronic obstructive pulmonary disease, arterial hypertension, and atrial fibrillation which has been treated with amiodarone for six years. Sputum smears were negative for mycobacteria, and by the diagnostic elimination method for specific, non-specific and malignant disease the diagnosis of amiodarone pulmonary toxicity was made. Fiberoptic bronchoscopy and pathohistological findings of bronchiolitis obliterans organizing pneumonia confirmed the diagnosis. As the first therapeutic approach, amiodarone therapy was stopped.Then, systemic therapy with methylprednisolone 21 (sodium succinate) 40 mg i.v. daily during the first two weeks was initiated and continued with daily dose of methylprednisolone 30 mg orally during the next three months. The patient showed a marked subjective improvement during the first week, which was followed by the improvement of respiratory function and withdrawal of pulmonary changes with complete radiographic and CT resolution after eight months. Amiodarone pulmonary toxicity should be taken into consideration, especially in elderly patients with respiratory symptoms and pulmonary changes, even if only a low dose of amiodarone is administred over a longer time period.
  • Publisher: Serbia: Serbian Medical Society
  • Language: Serbian;English
  • Identifier: ISSN: 0370-8179
    EISSN: 2406-0895
    DOI: 10.2298/SARH1408480V
    PMID: 25233696
  • Source: MEDLINE
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait