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Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina

Heliyon, 2024-01, Vol.10 (1), p.e22610-e22610, Article e22610 [Peer Reviewed Journal]

2023 The Authors ;2023 The Authors. ;ISSN: 2405-8440 ;EISSN: 2405-8440 ;DOI: 10.1016/j.heliyon.2023.e22610 ;PMID: 38163174

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  • Title:
    Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
  • Author: Barcudi, Danilo ; Blasko, Enrique ; Gonzalez, María José ; Gagetti, Paula ; Lamberghini, Ricardo ; Garnero, Analía ; Sarkis, Claudia ; Faccone, Diego ; Lucero, Celeste ; Tosoroni, Dario ; Bocco, José L. ; Corso, Alejandra ; Sola, Claudia
  • Subjects: Argentina ; CA-MRSA-ST30-IV ; CA-MRSA-ST5-IV ; CA-MRSA-USA300-LV ; CC398-MSSA ; CC97-MRSA ; Community-onset-(CO) infections ; Healthcare-associated-(HA) infections ; MRSA ; MSSA ; S. aureus
  • Is Part Of: Heliyon, 2024-01, Vol.10 (1), p.e22610-e22610, Article e22610
  • Description: Staphylococcus aureus-(SA) is widespread among healthcare-associated-(HA) and the community-associated-(CA) infections. However, the contributions of MRSA and MSSA to the SA overall burden remain unclear. In a nationally-representative-survey conducted in Argentina, 668 SA clinical isolates from 61 hospitals were examined in a prospective, cross-sectional, multicenter study in April 2015. The study aimed to analyze MRSA molecular epidemiology, estimate overall SA infection incidence (MSSA, MRSA, and genotypes) in community-onset (CO: HACO, Healthcare-Associated-CO and CACO, Community-Associated-CO) and healthcare-onset (HO: HAHO, Healthcare-associated-HO) infections, stratified by age groups. Additionally temporal evolution was estimated by comparing this study's (2015) incidence values with a previous study (2009) in the same region. Erythromycin-resistant-MSSA and all MRSA strains were genetically typed. The SA total-infections (TI) overall-incidence was 49.1/100,000 monthly-visits, 25.1 and 24.0 for MRSA and MSSA respectively (P = 0.5889), in April 2015. In adults with invasive-infections (INVI), MSSA was 15.7 and MRSA was 11.8 (P = 0.0288), 1.3-fold higher. HA SA infections, both MSSA and MRSA, surpassed CA infections by over threefold. During 2009–2015, there was a significant 23.4 % increase in the SA infections overall-incidence, mainly driven by MSSA, notably a 54.2 % increase in INVI among adults, while MRSA infection rates remained stable. The MSSA rise was accompanied by increased antimicrobial resistance, particularly to erythromycin, linked to MSSA-CC398-t1451-ermT + -IEC+-pvl- emergence. The SA-infections rise was primarily attributed to community-onset-infections (37.3 % and 62.4 % increase for TI and INVI, respectively), particularly HACO-MSSA and HACO-MRSA in adults, as well as CACO-MSSA. The main CA-MRSA-PFGE-typeN-ST30-SCCmecIVc-PVL+/− clone along with other clones (USA300-ST8-IV-LV-PVL+/−, PFGE-typeDD-ST97-IV- PVL−) added to rather than replaced CA-MRSA-PFGE-typeI-ST5-SCCmecIVa-PVL+/− clone in HA invasive-infections. They also displaced clone HA-MRSA-PFGE-typeA-ST5-SCCmecI, mainly in HAHO infections. The overall-burden of SA infections is rising in Argentina, driven primarily by community-onset MSSA, particularly in adults, linked to increased erythromycin-resistance and MSSA-CC398-t1451-ermT + -IEC+-pvl- emergence. Novel knowledge and transmission-control strategies are required for MSSA. •Since 2009, overall burden of SA infections has risen, driven by CO MSSA, Argentina.•SA infections rate in 2015: 49.1/100,000 monthly visits, showing a rising evolution.•Higher (>3 fold) HA/(HACO and HAHO) SA infections rates than CA/(CACO) infections.•CA-MRSA ST30-IV clone added to rather than replace ST5-IV in HA invasive infections.•MSSA infections increased by 54.2 %, with an ERY resistance rise linked to CC398.
  • Publisher: England: Elsevier Ltd
  • Language: English
  • Identifier: ISSN: 2405-8440
    EISSN: 2405-8440
    DOI: 10.1016/j.heliyon.2023.e22610
    PMID: 38163174
  • Source: PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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