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POS0481 BONE EDEMA IN MRI IS MORE ASSOCIATED WITH RAPID RADIOGRAPHIC PROGRESSION THAN CLINICALLY RELEVANT RADIOGRAPHIC PROGRESSION

Annals of the rheumatic diseases, 2023, Vol.82 (Suppl 1), p.501-502 [Peer Reviewed Journal]

ISSN: 0003-4967 ;EISSN: 1468-2060 ;DOI: 10.1136/annrheumdis-2023-eular.5692

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  • Title:
    POS0481 BONE EDEMA IN MRI IS MORE ASSOCIATED WITH RAPID RADIOGRAPHIC PROGRESSION THAN CLINICALLY RELEVANT RADIOGRAPHIC PROGRESSION
  • Author: Katayama, K. ; Okubo, T. ; Sato, T. ; Kawahata, T. ; Tanaka, K. ; Yuichi, M. ; Abe, S. ; Ito, H.
  • Is Part Of: Annals of the rheumatic diseases, 2023, Vol.82 (Suppl 1), p.501-502
  • Description: Background Rapid radiographic progression (RRP) is selected as one of the risk factors for difficult- to- treat RA, which needs to be resolved as soon as possible. Logistic progression models for RRP have been reported for a long time. Vanier et al. recently reported a newly logistic model which is constituted by high CRP levels (>30mg/L), the number of swollen joints, RF positivity, and the existence of bone erosion by pooling individual data from 2 cohorts and 3 clinical trials. On the other hand, EULAR recommendations for imaging were published, in which MRI bone oedema was an independent and strong predictor for joint destruction. We previously reported that extensive bone marrow edema (BE) determined by hand MRI is a prognostic indicator for rapid radiographic progression in MTX inadequate response to early RA treated with MTX+ Adalimumab combination therapy [1]. Objectives To clarify, association of BE with RRP using the clinical data in RA patients treated with conventional synthetic(cs) DMARDs. Methods At first, baseline data of 108 non-RRP patients and 47 clinically relevant radiographic progression (CRRP) +RRP patients were statistically compared. Secondly, background data of 13 CRRP and 34 RRP patients were compared. MRI of affected joints (mostly hands) were taken and patents were divided into two groups by existence or non-existence of BE. Results As shown in Table 1A, short duration, high BE rate, high DAS28-ESR (baseline), high CRP levels, high mTSS, high yearly progression of mTSS were observed in RRP +CRRP group compared with non-RRP. Table 1B showed that only the rate of BE is higher in RRP group compared with CRRP group. Conclusion BE may be a possible prognostic factor for RRP and more associated with RRP than CRRP. Reference [1]Katayama K, ACR meeting, SAT0046,2014 Table 1A. Table 1B. Acknowledgements: NIL. Disclosure of Interests None Declared.
  • Language: English
  • Identifier: ISSN: 0003-4967
    EISSN: 1468-2060
    DOI: 10.1136/annrheumdis-2023-eular.5692
  • Source: AUTh Library subscriptions: ProQuest Central
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