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Confronting the human papillomavirus-HIV intersection: Cervical cytology implications for Kenyan women living with HIV

Southern African journal of HIV medicine, 2023, Vol.24 (1), p.1508-1508 [Peer Reviewed Journal]

2023. The Authors. ;COPYRIGHT 2023 African Online Scientific Information Systems (Pty) Ltd t/a AOSIS ;2023. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2023. The Authors 2023 ;This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 1608-9693 ;ISSN: 2078-6751 ;EISSN: 2078-6751 ;DOI: 10.4102/SAJHIVMED.V24I1.1508 ;PMID: 37928501

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Title:
Confronting the human papillomavirus-HIV intersection: Cervical cytology implications for Kenyan women living with HIV
Author: Kangethe, James M ; Gichuhi, Stephen ; Odari, Eddy ; Pintye, Jillian ; Mutai, Kenneth ; Abdullahi, Leila ; Maiyo, Alex ; Mureithi, Marianne W
Subjects: Acquired immune deficiency syndrome ; AIDS ; Algorithms ; Analysis ; Annual reports ; Antiretroviral therapy ; Biology ; Cancer therapies ; Cellular biology ; Cervical cancer ; cervical cytology ; Cryotherapy ; Cytology ; Genotypes ; Genotyping ; Health Care Sciences & Services ; Health Policy & Services ; high-risk human papillomavirus ; Highly active antiretroviral therapy ; HIV ; HIV (Viruses) ; HIV patients ; Human immunodeficiency virus ; Human papillomavirus ; Immunology ; Infection ; Infections ; kenya ; Medical screening ; Mortality ; Original Research ; Papillomaviruses ; Prevention ; Vaccines ; Women ; women living with hiv ; Womens health
Is Part Of: Southern African journal of HIV medicine, 2023, Vol.24 (1), p.1508-1508
Description: High-risk human papillomavirus (HR-HPV) is the primary cause of cervical cancer, leading to over 311 000 global deaths, mainly in low- and middle-income countries. Kenyan women living with HIV (WLHIV) face a disproportionate burden of HR-HPV. We determined the prevalence of HR-HPV infections and their association with cervical cytology findings among Kenyan WLHIV. We conducted a cross-sectional study among WLHIV attending the HIV care and treatment clinic at the Kenyatta National Hospital (KNH), Kenya's national referral hospital. Study nurses collected a cervical sample with a cytobrush for HR-HPV genotyping using Gene Xpert assays and HPV Genotypes 14 Real-TM Quant V67-100FRT. Bivariate analysis explored the associations. We enrolled 647 WLHIV (mean age of 42.8 years), with 97.2% on antiretroviral therapy (ART) and 79% with a suppressed viral load (< 50 copies/mL plasma). The prevalence of any and vaccine-preventable HR-HPV was 34.6% and 29.4%, respectively, with HPV 52 being the most common genotype (13.4%). Among WLHIV with HR-HPV infections, 21.4% had abnormal cervical cytology. Women with multiple HR-HPV infections were more likely to have abnormal cytology compared to those with single HR-HPV infections (34.9 vs 9.3%, adjusted odds ratio [aOR] = 6.2, 95% confidence interval [CI]: 2.7-14.1, = 0.001). Women with HR-HPV infection (single or multiple) were more likely to be on the second-line ART regimen compared to those without HR-HPV infections (53.1% vs 46.7%, aOR = 2.3, 95% CI: 1.3-4.1, = 0.005). Among WLHIV at KNH, abnormal cytology was common and more frequent among women with multiple HR-HPV infections.
Publisher: South Africa: African Online Scientific Information Systems (Pty) Ltd t/a AOSIS
Language: English;Portuguese
Identifier: ISSN: 1608-9693
ISSN: 2078-6751
EISSN: 2078-6751
DOI: 10.4102/SAJHIVMED.V24I1.1508
PMID: 37928501
Source: SciELO
African Journals (Open access)
Alma/SFX Local Collection
PubMed Central (PMC)
ProQuest Central
DOAJ Directory of Open Access Journals

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Confronting the human papillomavirus-HIV intersection: Cervical cytology implications for Kenyan women living with HIV

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