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Prediabetes: a high-risk state for diabetes development

The Lancet (British edition), 2012-06, Vol.379 (9833), p.2279-2290 [Peer Reviewed Journal]

Elsevier Ltd ;2012 Elsevier Ltd ;2015 INIST-CNRS ;Copyright © 2012 Elsevier Ltd. All rights reserved. ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(12)60283-9 ;PMID: 22683128 ;CODEN: LANCAO

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Title:
Prediabetes: a high-risk state for diabetes development
Author: Tabák, Adam G, Dr ; Herder, Christian, PhD ; Rathmann, Wolfgang, MD ; Brunner, Eric J, PhD ; Kivimäki, Mika, Prof
Subjects: Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Diabetes Complications - prevention & control ; Diabetes. Impaired glucose tolerance ; diabetic retinopathy ; Disease Progression ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; experts ; General aspects ; Global Health ; glucose ; Glycated Hemoglobin - metabolism ; Humans ; hyperglycemia ; Hyperglycemia - blood ; Hyperglycemia - prevention & control ; Hypoglycemic Agents - therapeutic use ; insulin resistance ; Internal Medicine ; kidney diseases ; Life Style ; lifestyle ; Medical sciences ; Microcirculation ; peripheral nervous system diseases ; Prediabetic State - blood ; Prediabetic State - complications ; Prediabetic State - epidemiology ; Prediabetic State - prevention & control ; relative risk ; Risk Reduction Behavior
Is Part Of: The Lancet (British edition), 2012-06, Vol.379 (9833), p.2279-2290
Description: Prediabetes (intermediate hyperglycaemia) is a high-risk state for diabetes that is defined by glycaemic variables that are higher than normal, but lower than diabetes thresholds. 5–10% of people per year with prediabetes will progress to diabetes, with the same proportion converting back to normoglycaemia. Prevalence of prediabetes is increasing worldwide and experts have projected that more than 470 million people will have prediabetes by 2030. Prediabetes is associated with the simultaneous presence of insulin resistance and β-cell dysfunction—abnormalities that start before glucose changes are detectable. Observational evidence shows associations between prediabetes and early forms of nephropathy, chronic kidney disease, small fibre neuropathy, diabetic retinopathy, and increased risk of macrovascular disease. Multifactorial risk scores using non-invasive measures and blood-based metabolic traits, in addition to glycaemic values, could optimise estimation of diabetes risk. For prediabetic individuals, lifestyle modification is the cornerstone of diabetes prevention, with evidence of a 40–70% relative-risk reduction. Accumulating data also show potential benefits from pharmacotherapy.
Publisher: Kidlington: Elsevier Ltd
Language: English
Identifier: ISSN: 0140-6736
EISSN: 1474-547X
DOI: 10.1016/S0140-6736(12)60283-9
PMID: 22683128
CODEN: LANCAO
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Prediabetes: a high-risk state for diabetes development

Elsevier Ltd ;2012 Elsevier Ltd ;2015 INIST-CNRS ;Copyright © 2012 Elsevier Ltd. All rights reserved. ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(12)60283-9 ;PMID: 22683128 ;CODEN: LANCAO

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