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Integrative analysis of 111 reference human epigenomes

Nature (London), 2015-02, Vol.518 (7539), p.317-330 [Tạp chí có phản biện]

COPYRIGHT 2015 Nature Publishing Group ;COPYRIGHT 2015 Nature Publishing Group ;Copyright Nature Publishing Group Feb 19, 2015 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature14248 ;PMID: 25693563 ;CODEN: NATUAS

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Integrative analysis of 111 reference human epigenomes
Tác giả: Kundaje, Anshul ; Meuleman, Wouter ; Ernst, Jason ; Bilenky, Misha ; Yen, Angela ; Heravi-Moussavi, Alireza ; Kheradpour, Pouya ; Zhang, Zhizhuo ; Wang, Jianrong ; Ziller, Michael J ; Amin, Viren ; Whitaker, John W ; Schultz, Matthew D ; Ward, Lucas D ; Sarkar, Abhishek ; Quon, Gerald ; Sandstrom, Richard S ; Eaton, Matthew L ; Wu, Yi-Chieh ; Pfenning, Andreas R ; Wang, Xinchen ; Claussnitzer, Melina ; Liu, Yaping ; Coarfa, Cristian ; Harris, R Alan ; Shoresh, Noam ; Epstein, Charles B ; Gjoneska, Elizabeta ; Leung, Danny ; Xie, Wei ; Hawkins, R David ; Lister, Ryan ; Hong, Chibo ; Gascard, Philippe ; Mungall, Andrew J ; Moore, Richard ; Chuah, Eric ; Tam, Angela ; Canfield, Theresa K ; Hansen, R Scott ; Kaul, Rajinder ; Sabo, Peter J ; Bansal, Mukul S ; Carles, Annaick ; Dixon, Jesse R ; Farh, Kai-How ; Feizi, Soheil ; Karlic, Rosa ; Kim, Ah-Ram ; Kulkarni, Ashwinikumar ; Li, Daofeng ; Lowdon, Rebecca ; Elliott, GiNell ; Mercer, Tim R ; Neph, Shane J ; Onuchic, Vitor ; Polak, Paz ; Rajagopal, Nisha ; Ray, Pradipta ; Sallari, Richard C ; Siebenthall, Kyle T ; Sinnott-Armstrong, Nicholas A ; Stevens, Michael ; Thurman, Robert E ; Wu, Jie ; Zhang, Bo ; Zhou, Xin ; Beaudet, Arthur E ; Boyer, Laurie A ; De Jager, Philip L ; Farnham, Peggy J ; Fisher, Susan J ; Haussler, David ; Jones, Steven J M ; Li, Wei ; Marra, Marco A ; McManus, Michael T ; Sunyaev, Shamil ; Thomson, James A ; Tlsty, Thea D ; Tsai, Li-Huei ; Wang, Wei ; Waterland, Robert A ; Zhang, Michael Q ; Chadwick, Lisa H ; Bernstein, Bradley E ; Costello, Joseph F ; Ecker, Joseph R ; Hirst, Martin ; Meissner, Alexander ; Milosavljevic, Aleksandar ; Ren, Bing ; Stamatoyannopoulos, John A ; Wang, Ting ; Kellis, Manolis
Chủ đề: Base Sequence ; Cell Lineage - genetics ; Cells, Cultured ; Chromatin - chemistry ; Chromatin - genetics ; Chromatin - metabolism ; Chromosomes, Human - chemistry ; Chromosomes, Human - genetics ; Chromosomes, Human - metabolism ; Datasets as Topic ; Deoxyribonucleic acid ; DNA ; DNA - chemistry ; DNA - genetics ; DNA - metabolism ; DNA Methylation ; Enhancer Elements, Genetic - genetics ; Enzymes ; Epigenesis, Genetic - genetics ; Epigenetic inheritance ; Epigenomics ; Gene expression ; Genetic research ; Genetic Variation - genetics ; Genome, Human - genetics ; Genome-Wide Association Study ; Genomes ; Genomics ; Histones - metabolism ; Human genome ; Humans ; Organ Specificity - genetics ; Reference Values ; RNA - genetics
Là 1 phần của: Nature (London), 2015-02, Vol.518 (7539), p.317-330
Mô tả: The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here we describe the integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation and human disease.
Nơi xuất bản: England: Nature Publishing Group
Ngôn ngữ: English
Số nhận dạng: ISSN: 0028-0836
EISSN: 1476-4687
DOI: 10.1038/nature14248
PMID: 25693563
CODEN: NATUAS
Nguồn: ProQuest One Psychology
MEDLINE
ProQuest Central

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Integrative analysis of 111 reference human epigenomes

COPYRIGHT 2015 Nature Publishing Group ;COPYRIGHT 2015 Nature Publishing Group ;Copyright Nature Publishing Group Feb 19, 2015 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature14248 ;PMID: 25693563 ;CODEN: NATUAS

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