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Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging

Human brain mapping, 2021-04, Vol.42 (6), p.1626-1640 [Peer Reviewed Journal]

2020 The Authors. published by Wiley Periodicals LLC. ;2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. ;COPYRIGHT 2021 Wiley Subscription Services, Inc. ;2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;info:eu-repo/semantics/openAccess ;ISSN: 1065-9471 ;EISSN: 1097-0193 ;DOI: 10.1002/hbm.25316 ;PMID: 33314530

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Title:
Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging
Author: Anatürk, Melis ; Kaufmann, Tobias ; Cole, James H. ; Suri, Sana ; Griffanti, Ludovica ; Zsoldos, Enikő ; Filippini, Nicola ; Singh‐Manoux, Archana ; Kivimäki, Mika ; Westlye, Lars T. ; Ebmeier, Klaus P. ; Lange, Ann‐Marie G.
Subjects: Age ; Age Factors ; Aged ; Aged, 80 and over ; Aging ; Aging - physiology ; Alzheimer's disease ; Analysis ; Brain ; Brain - anatomy & histology ; Brain - diagnostic imaging ; Brain - physiology ; brain maintenance ; Cognition ; Cognitive ability ; cognitive reserve ; Cognitive Reserve - physiology ; Cohort Studies ; Female ; Gerontology ; Humans ; Intelligence ; Intelligence - physiology ; Learning algorithms ; Life Style ; lifestyle ; Lifestyles ; Machine Learning ; Magnetic Resonance Imaging ; Maintenance ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Neurodegeneration ; neuroimaging ; Older people ; Preservation ; Rheumatoid factor ; trajectories
Is Part Of: Human brain mapping, 2021-04, Vol.42 (6), p.1626-1640
Description: The concept of brain maintenance refers to the preservation of brain integrity in older age, while cognitive reserve refers to the capacity to maintain cognition in the presence of neurodegeneration or aging‐related brain changes. While both mechanisms are thought to contribute to individual differences in cognitive function among older adults, there is currently no “gold standard” for measuring these constructs. Using machine‐learning methods, we estimated brain and cognitive age based on deviations from normative aging patterns in the Whitehall II MRI substudy cohort (N = 537, age range = 60.34–82.76), and tested the degree of correspondence between these constructs, as well as their associations with premorbid IQ, education, and lifestyle trajectories. In line with established literature highlighting IQ as a proxy for cognitive reserve, higher premorbid IQ was linked to lower cognitive age independent of brain age. No strong evidence was found for associations between brain or cognitive age and lifestyle trajectories from midlife to late life based on latent class growth analyses. However, post hoc analyses revealed a relationship between cumulative lifestyle measures and brain age independent of cognitive age. In conclusion, we present a novel approach to characterizing brain and cognitive maintenance in aging, which may be useful for future studies seeking to identify factors that contribute to brain preservation and cognitive reserve mechanisms in older age. Using machine learning, we estimated brain and cognitive age based on deviations from normative aging patterns in the Whitehall II MRI substudy cohort, and tested the degree of correspondence between these constructs, as well as their associations with premorbid IQ, education, and lifestyle trajectories. The study presents a novel approach to characterizing brain and cognitive maintenance in aging, which may be useful for future studies seeking to identify factors that contribute to brain preservation and cognitive reserve in older age.
Publisher: Hoboken, USA: John Wiley & Sons, Inc
Language: English;Norwegian
Identifier: ISSN: 1065-9471
EISSN: 1097-0193
DOI: 10.1002/hbm.25316
PMID: 33314530
Source: Journals@Ovid Open Access Journal Collection Rolling
MEDLINE
NORA Norwegian Open Research Archives
PubMed Central
DOAJ Directory of Open Access Journals

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Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging

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