skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease

Alzheimer's & dementia : translational research & clinical interventions, 2018, Vol.4 (1), p.28-36 [Peer Reviewed Journal]

2017 The Authors ;2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association. ;2017 The Authors 2017 ;ISSN: 2352-8737 ;EISSN: 2352-8737 ;DOI: 10.1016/j.trci.2017.11.002 ;PMID: 29955649

Full text available

Citations Cited by
  • Title:
    Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease
  • Author: Taylor, Matthew K. ; Sullivan, Debra K. ; Mahnken, Jonathan D. ; Burns, Jeffrey M. ; Swerdlow, Russell H.
  • Subjects: Alzheimer's disease ; Cognition ; Ketogenic diet ; Low-carbohydrate diet ; Medium-chain triglyceride
  • Is Part Of: Alzheimer's & dementia : translational research & clinical interventions, 2018, Vol.4 (1), p.28-36
  • Description: We assessed the feasibility and cognitive effects of a ketogenic diet (KD) in participants with Alzheimer's disease. The Ketogenic Diet Retention and Feasibility Trial featured a 3-month, medium-chain triglyceride–supplemented KD followed by a 1-month washout in clinical dementia rating (CDR) 0.5, 1, and 2 participants. We obtained urine acetoacetate, serum β-hydroxybutyrate, food record, and safety data. We administered the Alzheimer's Disease Assessment Scale-cognitive subscale and Mini–Mental State Examination before the KD, and following the intervention and washout. We enrolled seven CDR 0.5, four CDR 1, and four CDR 2 participants. One CDR 0.5 and all CDR 2 participants withdrew citing caregiver burden. The 10 completers achieved ketosis. Most adverse events were medium-chain triglyceride–related. Among the completers, the mean of the Alzheimer's Disease Assessment Scale-cognitive subscale score improved by 4.1 points during the diet (P = .02) and reverted to baseline after the washout. This pilot trial justifies KD studies in mild Alzheimer's disease. •The medium-chain triglyceride–supplemented KD was feasible in very mild (clinical dementia rating [CDR] 0.5) and mild (CDR 1) Alzheimer's disease participants, as 10 of 11 participants adhered to the dietary protocol.•The medium chain triglyceride-supplemented KD was not feasible in moderate (CDR 2) Alzheimer's disease participants as all four of these participants withdrew from the study.•Dietary compliant participants had a 4.1-point mean improvement on Alzheimer's Disease Assessment Scale-cognitive subscale scores from baseline to the end of the diet. Alzheimer's Disease Assessment Scale-cognitive subscale improvements diminished after a 1-month diet washout period.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 2352-8737
    EISSN: 2352-8737
    DOI: 10.1016/j.trci.2017.11.002
    PMID: 29955649
  • Source: Journals@Ovid Open Access Journal Collection Rolling
    PubMed Central
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait