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Antidepressants increase neural progenitor cells in the human hippocampus

Neuropsychopharmacology (New York, N.Y.), 2009-10, Vol.34 (11), p.2376-2389 [Peer Reviewed Journal]

2009 INIST-CNRS ;Copyright Nature Publishing Group Oct 2009 ;ISSN: 0893-133X ;EISSN: 1740-634X ;DOI: 10.1038/npp.2009.75 ;PMID: 19606083 ;CODEN: NEROEW

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Title:
Antidepressants increase neural progenitor cells in the human hippocampus
Author: BOLDRINI, Maura ; UNDERWOOD, Mark D ; HEN, René ; ROSOKLIJA, Gorazd B ; DWORK, Andrew J ; MANN, J. John ; ARANGO, Victoria
Subjects: Adolescent ; Adult ; Adult and adolescent clinical studies ; Adult Stem Cells - drug effects ; Adult Stem Cells - physiology ; Aging ; Antidepressants ; Antidepressive Agents - pharmacology ; Antidepressive Agents, Tricyclic - pharmacology ; Biological and medical sciences ; Cell cycle ; Cell Division - drug effects ; Cell Division - physiology ; Dentate Gyrus - drug effects ; Dentate Gyrus - pathology ; Dentate Gyrus - physiopathology ; Depression ; Depressive Disorder, Major - drug therapy ; Depressive Disorder, Major - physiopathology ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Labeling ; Male ; Medical sciences ; Mental depression ; Middle Aged ; Mood disorders ; Nervous system ; Neurogenesis ; Neurons ; Neurons - drug effects ; Neurons - physiology ; Neuropathology ; Neuropharmacology ; Neurosciences ; Organ Size ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pharmacology. Drug treatments ; Primates ; Psychiatry ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Rodents ; Serotonin Uptake Inhibitors - pharmacology ; Sex Characteristics ; Young Adult
Is Part Of: Neuropsychopharmacology (New York, N.Y.), 2009-10, Vol.34 (11), p.2376-2389
Description: Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) increase neurogenesis in the dentate gyrus (DG) of rodents and nonhuman primates. We determined whether SSRIs or TCAs increase neural progenitor (NPCs) and dividing cells in the human DG in major depressive disorder (MDD). Whole frozen hippocampi from untreated subjects with MDD (N=5), antidepressant-treated MDD (MDDT, N=7), and controls (C, N=7) were fixed, sectioned, and immunostained for NPCs and dividing cell markers (nestin and Ki-67, respectively), NeuN and GFAP, in single and double labeling. NPC and dividing cell numbers in the DG were estimated by stereology. Clinical data were obtained by psychological autopsy, and by toxicological and neuropathological examination performed on all subjects. NPCs decreased with age (p = 0.034). Females had more NPCs than males (p = 0.023). Correcting for age and sex, MDDT receiving SSRIs had more NPCs than untreated MDD (p < or = 0.001) and controls (p < or = 0.001), NPCs were not different in SSRI- and TCA-treated MDDT (p = 0.169). Dividing cell number, unaffected by age or sex, was greater in MDDT receiving TCAs than in untreated MDD (p < or = 0.001), SSRI-treated MDD (p = 0.001), and controls (p < or = 0.001). The increase of NPCs and dividing cells in MDDT was localized to the rostral DG. MDDT had a larger DG volume compared with untreated MDD or controls (p = 0.009). Antidepressants increase NPC number in the anterior human DG. Whether this finding is critical or necessary for the antidepressants effect remains to be determined.
Publisher: Basingstoke: Nature Publishing Group
Language: English
Identifier: ISSN: 0893-133X
EISSN: 1740-634X
DOI: 10.1038/npp.2009.75
PMID: 19606083
CODEN: NEROEW
Source: ProQuest One Psychology
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
ProQuest Central

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Antidepressants increase neural progenitor cells in the human hippocampus

2009 INIST-CNRS ;Copyright Nature Publishing Group Oct 2009 ;ISSN: 0893-133X ;EISSN: 1740-634X ;DOI: 10.1038/npp.2009.75 ;PMID: 19606083 ;CODEN: NEROEW

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