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A guide to immunometabolism for immunologists

Nature reviews. Immunology, 2016-09, Vol.16 (9), p.553-565 [Peer Reviewed Journal]

COPYRIGHT 2016 Nature Publishing Group ;COPYRIGHT 2016 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2016 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/nri.2016.70 ;PMID: 27396447

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  • Title:
    A guide to immunometabolism for immunologists
  • Author: O'Neill, Luke A J ; Kishton, Rigel J ; Rathmell, Jeff
  • Subjects: Animals ; Cell metabolism ; Disease susceptibility ; Humans ; Immune response ; Immune System - metabolism ; Medical research ; Medicine, Experimental ; Observations
  • Is Part Of: Nature reviews. Immunology, 2016-09, Vol.16 (9), p.553-565
  • Description: In recent years a substantial number of findings have been made in the area of immunometabolism, by which we mean the changes in intracellular metabolic pathways in immune cells that alter their function. Here, we provide a brief refresher course on six of the major metabolic pathways involved (specifically, glycolysis, the tricarboxylic acid (TCA) cycle, the pentose phosphate pathway, fatty acid oxidation, fatty acid synthesis and amino acid metabolism), giving specific examples of how precise changes in the metabolites of these pathways shape the immune cell response. What is emerging is a complex interplay between metabolic reprogramming and immunity, which is providing an extra dimension to our understanding of the immune system in health and disease.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1474-1733
    EISSN: 1474-1741
    DOI: 10.1038/nri.2016.70
    PMID: 27396447
  • Source: AUTh Library subscriptions: ProQuest Central
    MEDLINE
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