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The monocrotaline model of pulmonary hypertension in perspective

American journal of physiology. Lung cellular and molecular physiology, 2012-02, Vol.302 (4), p.L363-L369 [Peer Reviewed Journal]

Copyright American Physiological Society Feb 2012 ;ISSN: 1040-0605 ;EISSN: 1522-1504 ;DOI: 10.1152/ajplung.00212.2011 ;PMID: 21964406

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Title:
The monocrotaline model of pulmonary hypertension in perspective
Author: Gomez-Arroyo, Jose G ; Farkas, Laszlo ; Alhussaini, Aysar A ; Farkas, Daniela ; Kraskauskas, Donatas ; Voelkel, Norbert F ; Bogaard, Harm J
Subjects: Acute Lung Injury - chemically induced ; Acute Lung Injury - physiopathology ; Animals ; Cardiology ; Chemical and Drug Induced Liver Injury - pathology ; Chemical and Drug Induced Liver Injury - physiopathology ; Disease Models, Animal ; Humans ; Hypertension ; Hypertension, Pulmonary - chemically induced ; Hypertension, Pulmonary - pathology ; Hypertension, Pulmonary - physiopathology ; Lung - blood supply ; Lung - pathology ; Monocrotaline ; Myocarditis - chemically induced ; Myocarditis - pathology ; Myocarditis - physiopathology ; Pathology ; Pulmonary arteries ; Rodents
Is Part Of: American journal of physiology. Lung cellular and molecular physiology, 2012-02, Vol.302 (4), p.L363-L369
Description: Severe forms of pulmonary arterial hypertension (PAH) are characterized by various degrees of remodeling of the pulmonary arterial vessels, which increases the pulmonary vascular resistance and right ventricular afterload, thus contributing to the development of right ventricle dysfunction and failure. Recent years have seen advances in the understanding of the pathobiology of PAH; however, many important questions remain unanswered. Elucidating the pathobiology of PAH continues to be critical to design new effective therapeutic strategies, and appropriate animal models of PAH are necessary to achieve the task. Although the monocrotaline rat model of PAH has contributed to a better understanding of vascular remodeling in pulmonary hypertension, we question the validity of this model as a preclinically relevant model of severe plexogenic PAH. Here we review pertinent publications that either have been forgotten or ignored, and we reexamine the monocrotaline model in the context of human forms of PAH.
Publisher: United States: American Physiological Society
Language: English
Identifier: ISSN: 1040-0605
EISSN: 1522-1504
DOI: 10.1152/ajplung.00212.2011
PMID: 21964406
Source: MEDLINE
Alma/SFX Local Collection

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The monocrotaline model of pulmonary hypertension in perspective

Copyright American Physiological Society Feb 2012 ;ISSN: 1040-0605 ;EISSN: 1522-1504 ;DOI: 10.1152/ajplung.00212.2011 ;PMID: 21964406

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