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DXA-derived Abdominal Lean Mass Correlates With MRI-derived Skeletal Muscle

Obesity (Silver Spring, Md.), 2022-11, Vol.30, p.204-204 [Peer Reviewed Journal]

Copyright Blackwell Publishing Ltd. Nov 2022 ;ISSN: 1930-7381 ;EISSN: 1930-739X

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  • Title:
    DXA-derived Abdominal Lean Mass Correlates With MRI-derived Skeletal Muscle
  • Author: Bea, Jennifer ; Chalke, Arushi ; Bland, Victoria ; Walker, Erika ; Lind, Kimberly ; Chen, Zhao ; Blew, Robert ; Odegaard, Andrew
  • Subjects: Abdomen ; Musculoskeletal system ; Womens health
  • Is Part Of: Obesity (Silver Spring, Md.), 2022-11, Vol.30, p.204-204
  • Description: Background: Abdominal skeletal muscle assessments from gold standard CT or MRI at time of cancer diagnosis are increasingly used as prognostic tools. The precision of estimates of abdominal skeletal muscle in the prevention setting (i.e. DXA) for the same region is not known. Methods: Dual-energy X-ray absorptiometry (DXA)-derived abdominal lean mass (LMab) was compared to MRI-derived skeletal muscle mass (SkM) for the single slice nearest L3-L4 among postmenopausal women enrolled in the Women's Health Initiative. Women underwent concurrent scans on MRI (n=67) and at least one DXA model (Hologic QDR4500 n = 67; QDR2000 and QDR4500 n = 42). The DXA abdominal region of interest was defined at the 4th lumbar vertebrae (5 cm wide) (APEX v4.0, Hologic, Inc.). MRIs were quantified using sliceOmatic software (v5.0 Rev-9b, Tomovision, Magog, Canada). Two independent raters performed repeat analyses for all images. Intraclass correlation coefficients (ICC) were computed for intra- and interrater reliability for DXA and MRI measures. Correlations between DXA and MRI were assessed by Spearman Rank Correlations. Preliminary linear regression adjusted for BMI and age was used to predict MRI SkM. Agreement between unadjusted and adjusted DXA LMab and MRI SkM was assessed using ICCs and Bland-Altman plots. Results: Mean age was 69.4±5.9 yrs. The MRI abdominal SkM was 0.09±0.02kg. DXA QDR4500 mean LMab was 1.92±0.31kg; QDR2000 was 1.68±0.31kg. All intra- and inter-rater ICCs were >0.99 for both MRI and DXA. MRI SkM correlations with DXA LMab were r=0.71 (QDR 2000) and r= 0.69 (QDR 4500; pall <0.0001). In adjusted models, DXA measures strongly predicted MRI SkM (Adj. R2 QDR2000 0.72; QDR4500: 0.65). Abdominal LM predicted by adjusted regression equation had high agreement with MRI SkM (ICC QDR2000 0.83; QDR4500 0.79). Conclusions: DXA-derived abdominal lean mass measures were highly correlated with MRI skeletal muscle and have strong agreement after adjusting for readily available clinical characteristics of BMI and age.
  • Publisher: Silver Spring: Blackwell Publishing Ltd
  • Language: English
  • Identifier: ISSN: 1930-7381
    EISSN: 1930-739X
  • Source: ProQuest Central
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