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Pancreatic Adenocarcinoma

The New England journal of medicine, 2014-09, Vol.371 (11), p.1039-1049 [Peer Reviewed Journal]

Copyright © 2014 Massachusetts Medical Society. All rights reserved. ;2015 INIST-CNRS ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMra1404198 ;PMID: 25207767 ;CODEN: NEJMAG

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Title:
Pancreatic Adenocarcinoma
Author: Ryan, David P ; Hong, Theodore S ; Bardeesy, Nabeel
Subjects: Adenocarcinoma ; Adenocarcinoma - diagnosis ; Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - therapy ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Care and treatment ; Chemotherapy ; Chemotherapy, Adjuvant ; Diagnosis ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Mutation ; Neoplasm Metastasis ; Neoplasm Staging ; Palliation ; Pancreas ; Pancreatic cancer ; Pancreatic Neoplasms - diagnosis ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - metabolism ; Pancreatic Neoplasms - therapy ; Patient outcomes ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins p21(ras) ; ras Proteins - genetics ; Risk Factors ; Tumors
Is Part Of: The New England journal of medicine, 2014-09, Vol.371 (11), p.1039-1049
Description: Cancer of the pancreas is predominantly adenocarcinoma and involves activating KRAS mutations in the large majority of cases. Surgical resection can be effective in localized disease; combination chemotherapy offers some palliation in advanced disease. Pancreatic ductal adenocarcinoma is the most lethal common cancer because it is usually diagnosed at an advanced stage and is resistant to therapy. In this article, we review current understanding of the biology and treatment of pancreatic adenocarcinoma. Epidemiology and Risk Factors Pancreatic adenocarcinoma is rarely diagnosed in persons younger than 40 years of age, and the median age at diagnosis is 71 years. Worldwide, the incidence of all types of pancreatic cancer (85% of which are adenocarcinomas) ranges from 1 to 10 cases per 100,000 people, is generally higher in developed countries and among men, and has remained stable . . .
Publisher: Waltham, MA: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMra1404198
PMID: 25207767
CODEN: NEJMAG
Source: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Pancreatic Adenocarcinoma

Copyright © 2014 Massachusetts Medical Society. All rights reserved. ;2015 INIST-CNRS ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMra1404198 ;PMID: 25207767 ;CODEN: NEJMAG

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