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Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis

The Lancet (British edition), 2012, Vol.380 (9854), p.1662-1673 [Peer Reviewed Journal]

Elsevier Ltd ;2012 Elsevier Ltd ;2015 INIST-CNRS ;Copyright © 2012 Elsevier Ltd. All rights reserved. ;ISSN: 0140-6736 ;ISSN: 1474-547X ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(12)61350-6 ;PMID: 23013602 ;CODEN: LANCAO

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Title:
Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis
Author: Fox, Caroline S, MD ; Matsushita, Kunihiro, MD ; Woodward, Mark, Prof ; Bilo, Henk JG, Prof ; Chalmers, John, Prof ; Heerspink, Hiddo J Lambers, PharmD ; Lee, Brian J, MD ; Perkins, Robert M, MD ; Rossing, Peter, Prof ; Sairenchi, Toshimi, PhD ; Tonelli, Marcello, Prof ; Vassalotti, Joseph A, MD ; Yamagishi, Kazumasa, MD ; Coresh, Josef, Prof ; de Jong, Paul E, Prof ; Wen, Chi-Pang, MD ; Nelson, Robert G, MD
Subjects: Aged ; albuminuria ; Albuminuria - mortality ; Albuminuria - physiopathology ; Biological and medical sciences ; Cardiovascular disease ; cardiovascular diseases ; Cardiovascular Diseases - mortality ; Cause of Death ; Diabetes ; Diabetes mellitus ; Diabetic Nephropathies - mortality ; Diabetic Nephropathies - physiopathology ; Diabetic Nephropathies - urine ; Epidemiology ; Female ; Filtration ; General aspects ; glomerular filtration rate ; Glomerular Filtration Rate - physiology ; Humans ; Hypertension ; Internal Medicine ; Kidney ; Kidney diseases ; Kidney Failure, Chronic - mortality ; Kidney Failure, Chronic - physiopathology ; Kidney Failure, Chronic - urine ; kidneys ; Male ; Medical sciences ; meta-analysis ; Middle Aged ; Mortality ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; prognosis ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Renal failure ; risk ; Risk Factors ; Studies ; Systematic review
Is Part Of: The Lancet (British edition), 2012, Vol.380 (9854), p.1662-1673
Description: Summary Background Chronic kidney disease is characterised by low estimated glomerular filtration rate (eGFR) and high albuminuria, and is associated with adverse outcomes. Whether these risks are modified by diabetes is unknown. Methods We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and end-stage renal disease (ESRD) associated with eGFR and albuminuria in individuals with and without diabetes. Findings We analysed data for 1 024 977 participants (128 505 with diabetes) from 30 general population and high-risk cardiovascular cohorts and 13 chronic kidney disease cohorts. In the combined general population and high-risk cohorts with data for all-cause mortality, 75 306 deaths occurred during a mean follow-up of 8·5 years (SD 5·0). In the 23 studies with data for cardiovascular mortality, 21 237 deaths occurred from cardiovascular disease during a mean follow-up of 9·2 years (SD 4·9). In the general and high-risk cohorts, mortality risks were 1·2–1·9 times higher for participants with diabetes than for those without diabetes across the ranges of eGFR and albumin-to-creatinine ratio (ACR). With fixed eGFR and ACR reference points in the diabetes and no diabetes groups, HR of mortality outcomes according to lower eGFR and higher ACR were much the same in participants with and without diabetes (eg, for all-cause mortality at eGFR 45 mL/min per 1·73 m2 [ vs 95 mL/min per 1·73 m2 ], HR 1·35; 95% CI 1·18–1·55; vs 1·33; 1·19–1·48 and at ACR 30 mg/g [ vs 5 mg/g], 1·50; 1·35–1·65 vs 1·52; 1·38–1·67). The overall interactions were not significant. We identified much the same findings for ESRD in the chronic kidney disease cohorts. Interpretation Despite higher risks for mortality and ESRD in diabetes, the relative risks of these outcomes by eGFR and ACR are much the same irrespective of the presence or absence of diabetes, emphasising the importance of kidney disease as a predictor of clinical outcomes. Funding US National Kidney Foundation.
Publisher: Kidlington: Elsevier Ltd
Language: English
Identifier: ISSN: 0140-6736
ISSN: 1474-547X
EISSN: 1474-547X
DOI: 10.1016/S0140-6736(12)61350-6
PMID: 23013602
CODEN: LANCAO
Source: ProQuest One Psychology
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Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis

Elsevier Ltd ;2012 Elsevier Ltd ;2015 INIST-CNRS ;Copyright © 2012 Elsevier Ltd. All rights reserved. ;ISSN: 0140-6736 ;ISSN: 1474-547X ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(12)61350-6 ;PMID: 23013602 ;CODEN: LANCAO

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