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J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

Journal of arrhythmia, 2016-10, Vol.32 (5), p.315-339 [Peer Reviewed Journal]

2016 Japanese Heart Rhythm Society ;COPYRIGHT 2016 John Wiley & Sons, Inc. ;Copyright John Wiley & Sons, Inc. Oct 2016 ;2016 Japanese Heart Rhythm Society. Published by Elsevier B.V. 2016 ;ISSN: 1880-4276 ;EISSN: 1883-2148 ;DOI: 10.1016/j.joa.2016.07.002 ;PMID: 27761155

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Title:
J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge
Author: Antzelevitch, Charles, PhD, FHRS ; Yan, Gan-Xin, MD, PhD ; Ackerman, Michael J., MD, PhD ; Borggrefe, Martin, MD ; Corrado, Domenico, MD, PhD ; Guo, Jihong, MD ; Gussak, Ihor, MD, PhD ; Hasdemir, Can, MD ; Horie, Minoru, MD ; Huikuri, Heikki, MD ; Ma, Changsheng, MD ; Morita, Hiroshi, MD, PhD ; Nam, Gi-Byoung, MD, PhD ; Sacher, Frederic, MD, PhD ; Shimizu, Wataru, MD, PhD ; Viskin, Sami, MD ; Wilde, Arthur A.M., MD, PhD, FHRS
Subjects: Brugada syndrome ; Cardiac arrhythmia ; Cardiology ; Cardiovascular ; Cardiovascular disease ; Conferences, meetings and seminars ; Early repolarization syndrome ; Electrocardiography ; Guideline ; Health care ; Heart ; Inherited cardiac arrhythmia syndrome ; J wave ; Jargon ; Patients ; Procainamide ; Sudden cardiac death ; Task forces ; Veins & arteries ; Ventricular fibrillation
Is Part Of: Journal of arrhythmia, 2016-10, Vol.32 (5), p.315-339
Description: [...]in 1 study, a repeat ajmaline challenge performed after puberty unmasked BrS in 23% of relatives with a previously negative drug test performed during childhood [64]. [...]1 study revealed that 1:23 individuals in the GO‐ESP population possess a previously published BrS‐associated variant that would prompt a “positive” genetic test had it been identified in a patient [201]. Family members may be referred for cardiopulmonary resuscitation training and advised to consider purchasing an automatic external defibrillator for home use. Because malignant ventricular arrhythmias are infrequent in asymptomatic patients with BrS [247] or ERP [44] and usually unrelated to physical activity, the presence of these patterns does not contraindicate participation in sports. Dimethyl lithospermate B, an extract of Danshen, a traditional Chinese herbal remedy, has been reported to slow inactivation of INa, thus increasing INa during the early phases of the AP and suppressing arrhythmogenesis in experimental models of BrS [350]. Because malignant ventricular arrhythmias are infrequent in asymptomatic patients with BrS [247] or ERP [44] and usually unrelated to physical activity, the presence of these patterns does not contraindicate participation in sports, although, as previously discussed, insufficient data are currently available to make definitive recommendations for participation in sports. 19.2 Early repolarization syndrome It is not surprising that the approach to therapy of ERS is similar to that of BrS, because the mechanisms underlying the 2 syndromes are potentially similar.
Publisher: Japan: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 1880-4276
EISSN: 1883-2148
DOI: 10.1016/j.joa.2016.07.002
PMID: 27761155
Source: Wiley Blackwell Open Access Collection

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J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

2016 Japanese Heart Rhythm Society ;COPYRIGHT 2016 John Wiley & Sons, Inc. ;Copyright John Wiley & Sons, Inc. Oct 2016 ;2016 Japanese Heart Rhythm Society. Published by Elsevier B.V. 2016 ;ISSN: 1880-4276 ;EISSN: 1883-2148 ;DOI: 10.1016/j.joa.2016.07.002 ;PMID: 27761155

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