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Macrophages Keep Your Gut Moving
Molecules and Cells, 2023, 46(11), , pp.672-674
[Peer Reviewed Journal]
ISSN: 1016-8478 ;EISSN: 0219-1032 ;DOI: 10.14348/molcells.2023.0125 ;PMID: 37968981
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Title:
Macrophages Keep Your Gut Moving
Author:
Lee, Chan Hee
;
Kim, Min-Seon
Subjects:
Gastrointestinal Tract
;
Macrophages
;
생물학
Is Part Of:
Molecules and Cells, 2023, 46(11), , pp.672-674
Description:
Schematic diagram of the interaction between the intestinal muscularis externa (MMΦ) macrophages and the enteric nervous system (ENS) neurons during different developmental periods. At the early postnatal stage, MMΦs play a critical role in ENS maturation and refinement through synaptic pruning and enteric neuron phagocytosis. In addition, during the adult stage, a specific MMΦ subset named neuron-associated (NA)-MMΦ, supports enteric neuronal survival and functions. Conversely, enteric neurons promote the phenotypic MMΦ changes by secreting transforming growth factor-β (TGFβ), transitioning them from a phagocytic phenotype in the early postnatal period to a neuroprotective and immune-surveillant phenotype in the young adult period. Disruptions in these interactions could lead to alterations in the enteric neuron numbers, ultimately resulting in reduced gut motility.
Publisher:
United States: 한국분자세포생물학회
Language:
English;Korean
Identifier:
ISSN: 1016-8478
EISSN: 0219-1032
DOI: 10.14348/molcells.2023.0125
PMID: 37968981
Source:
GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
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