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Efficacy of a Nasal Spray Containing Iota-Carrageenan in the Postexposure Prophylaxis of COVID-19 in Hospital Personnel Dedicated to Patients Care with COVID-19 Disease

International journal of general medicine, 2021-01, Vol.14, p.6277-6286 [Peer Reviewed Journal]

2021 Figueroa et al. ;COPYRIGHT 2021 Dove Medical Press Limited ;2021. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 Figueroa et al. 2021 Figueroa et al. ;ISSN: 1178-7074 ;EISSN: 1178-7074 ;DOI: 10.2147/IJGM.S328486 ;PMID: 34629893

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Title:
Efficacy of a Nasal Spray Containing Iota-Carrageenan in the Postexposure Prophylaxis of COVID-19 in Hospital Personnel Dedicated to Patients Care with COVID-19 Disease
Author: Figueroa, Juan Manuel ; Lombardo, Mónica Edith ; Dogliotti, Ariel ; Flynn, Luis Pedro ; Giugliano, Robert ; Simonelli, Guido ; Valentini, Ricardo ; Ramos, Agñel ; Romano, Pablo ; Marcote, Marcelo ; Michelini, Alicia ; Salvado, Alejandro ; Sykora, Emilio ; Kniz, Cecilia ; Kobelinsky, Marcelo ; Salzberg, David Manuel ; Jerusalinsky, Diana ; Uchitel, Osvaldo
Subjects: Antiviral agents ; Care and treatment ; Carrageenin ; Clinical Trial Report ; Coronaviruses ; covid-19 ; DNA polymerases ; Health aspects ; hospital workers ; Immunization ; Medical equipment ; Medical personnel ; Medical research ; Medicine, Experimental ; nasal ; Patients ; prophylaxis ; spray ; Sulfates ; Viruses
Is Part Of: International journal of general medicine, 2021-01, Vol.14, p.6277-6286
Description: Iota-Carrageenan (I-C) is a sulfate polysaccharide synthesized by red algae, with demonstrated antiviral activity and clinical efficacy as nasal spray in the treatment of common cold. In vitro, I-C inhibits SARS-CoV-2 infection in cell culture. Can a nasal spray with Iota-Carrageenan be useful in the prophylaxis of COVID-19 in health care workers managing patients with COVID-19 disease? This is a pilot pragmatic multicenter, randomized, double-blind, placebo-controlled study assessing the use of a nasal spray containing I-C in the prophylaxis of COVID-19 in hospital personnel dedicated to care of COVID-19 patients. Clinically healthy physicians, nurses, kinesiologists and other health care providers managing patients hospitalized for COVID-19 were assigned in a 1:1 ratio to receive four daily doses of I-C spray or placebo for 21 days. The primary end point was clinical COVID-19, as confirmed by reverse transcriptase polymerase chain reaction testing, over a period of 21 days. The trial is registered at ClinicalTrials.gov (NCT04521322). A total of 394 individuals were randomly assigned to receive I-C or placebo. Both treatment groups had similar baseline characteristics. The incidence of COVID-19 differs significantly between subjects receiving the nasal spray with I-C (2 of 196 [1.0%]) and those receiving placebo (10 of 198 [5.0%]). Relative risk reduction: 79.8% (95% CI 5.3 to 95.4; p=0.03). Absolute risk reduction: 4% (95% CI 0.6 to 7.4). In this pilot study a nasal spray with I-C showed significant efficacy in preventing COVID-19 in health care workers managing patients with COVID-19 disease. NCT04521322.
Publisher: New Zealand: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1178-7074
EISSN: 1178-7074
DOI: 10.2147/IJGM.S328486
PMID: 34629893
Source: GFMER Free Medical Journals
PubMed Central
Coronavirus Research Database
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals
Dove Press Free

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Efficacy of a Nasal Spray Containing Iota-Carrageenan in the Postexposure Prophylaxis of COVID-19 in Hospital Personnel Dedicated to Patients Care with COVID-19 Disease

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