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Incidence of clinical symptoms during long-duration orbital spaceflight

International journal of general medicine, 2016-01, Vol.9, p.383-391 [Peer Reviewed Journal]

COPYRIGHT 2016 Dove Medical Press Limited ;COPYRIGHT 2016 Dove Medical Press Limited ;2016. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2016 Crucian et al. This work is published and licensed by Dove Medical Press Limited 2016 ;ISSN: 1178-7074 ;EISSN: 1178-7074 ;DOI: 10.2147/ijgm.s114188 ;PMID: 27843335

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  • Title:
    Incidence of clinical symptoms during long-duration orbital spaceflight
  • Author: Crucian, Brian ; Babiak-Vazquez, Adriana ; Johnston, Smith ; Pierson, Duane L ; Ott, C Mark ; Sams, Clarence
  • Subjects: Allergic reaction ; Allergy ; Astronauts ; Binding sites ; clinical incidence ; Communicable diseases ; Cytokines ; Epidemiology ; Gene expression ; Illnesses ; Immune system ; immunity ; Information sources ; Medical records ; Medical research ; Medicine, Experimental ; Original Research ; Physiology ; Space stations ; Spaceflight ; Stress response ; Surveillance ; Viral infections
  • Is Part Of: International journal of general medicine, 2016-01, Vol.9, p.383-391
  • Description: The environment of spaceflight may elevate an astronaut's clinical risk for specific diseases. The purpose of this study was to derive, as accurately as currently possible, an assessment of in-flight clinical "incidence" data, based on observed clinical symptoms in astronauts on board the International Space Station (ISS). Electronic medical records were examined from 46 long-duration ISS crew members, each serving approximately a 6-month mission on board the ISS, constituting 20.57 total flight years. Incidence for immunological-related adverse health events or relevant clinical symptoms was tabulated in a non-identifiable fashion. Event categories included infectious diseases, allergies, and rashes/hypersensitivities. A subsequent re-evaluation of more notable events, either of prolonged duration or unresponsive to treatment, was performed. For the disease/symptom categories used in this evaluation, the ISS incidence rate was 3.40 events per flight year. Skin rashes were the most reported event (1.12/flight year) followed by upper respiratory symptoms (0.97/flight year) and various other (non-respiratory) infectious processes. During flight, 46% of crew members reported an event deemed "notable". Among the notable events, 40% were classified as rashes/hypersensitivities. Characterization of on-orbit rashes manifested as redness with irritation, and could present on a variety of body locations. Based on reported symptoms, astronauts experience adverse medical events of varying severity during long-duration spaceflights. The data suggests caution, from both a vehicle design and biomedical countermeasures perspective, as space agencies plan for prolonged deep space exploration missions.
  • Publisher: New Zealand: Dove Medical Press Limited
  • Language: English
  • Identifier: ISSN: 1178-7074
    EISSN: 1178-7074
    DOI: 10.2147/ijgm.s114188
    PMID: 27843335
  • Source: Open Access: PubMed Central
    Geneva Foundation Free Medical Journals at publisher websites
    AUTh Library subscriptions: ProQuest Central
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
    Dove Press Free
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