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Association between glycemic control and antidiabetic drugs in type 2 diabetes mellitus patients with cardiovascular complications

Drug design, development and therapy, 2015-01, Vol.9 (default), p.4735-4749 [Peer Reviewed Journal]

COPYRIGHT 2015 Dove Medical Press Limited ;COPYRIGHT 2015 Dove Medical Press Limited ;2015. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2015 Huri et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License 2015 ;ISSN: 1177-8881 ;EISSN: 1177-8881 ;DOI: 10.2147/DDDT.S87294 ;PMID: 26316711

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Title:
Association between glycemic control and antidiabetic drugs in type 2 diabetes mellitus patients with cardiovascular complications
Author: Huri, Hasniza Zaman ; Ling, Doris Yew Hui ; Ahmad, Wan Azman Wan
Subjects: Academic Medical Centers ; Acute coronary syndromes ; Adult ; Aged ; Aged, 80 and over ; Atherosclerosis ; Biomarkers - blood ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Cardiac arrhythmia ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - therapy ; Care and treatment ; Cholesterol ; Chronic illnesses ; Comorbidity ; Complications ; Demographics ; Demography ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - diagnosis ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetic retinopathy ; Disease Progression ; Drug therapy ; Drug Therapy, Combination ; Drugs ; Female ; Geriatrics ; Glucose ; Health care facilities ; Heart attacks ; Heart failure ; Hemoglobin ; Humans ; Hyperplasia ; Hypoglycemic Agents - adverse effects ; Hypoglycemic Agents - therapeutic use ; Insulin ; Malaysia - epidemiology ; Male ; Medical ethics ; Metabolism ; Methods ; Middle Aged ; Older people ; Original Research ; Patients ; Physiological aspects ; Retrospective Studies ; Risk Factors ; Stroke ; Sulfonylurea ; Treatment Outcome ; Type 2 diabetes
Is Part Of: Drug design, development and therapy, 2015-01, Vol.9 (default), p.4735-4749
Description: Cardiovascular disease (CVD) is a macrovascular complication in patients with type 2 diabetes mellitus (T2DM). To date, glycemic control profiles of antidiabetic drugs in cardiovascular (CV) complications have not been clearly elucidated. Therefore, this study was conducted retrospectively to assess the association of antidiabetic drugs and glycemic control with CV profiles in T2DM patients. The association of concurrent medications and comorbidities with glycemic control was also investigated. A total of 220 T2DM patients from the University of Malaya Medical Centre, Malaysia, who had at least one CV complication and who had been taking at least one antidiabetic drug for at least 3 months, were included. The associations of antidiabetics, cardiovascular diseases, laboratory parameters, concurrent medications, comorbidities, demographics, and clinical characteristics with glycemic control were investigated. Sulfonylureas in combination (P=0.002) and sulfonylurea monotherapy (P<0.001) were found to be associated with good glycemic control, whereas insulin in combination (P=0.051), and combination biguanides and insulin therapy (P=0.012) were found to be associated with poor glycemic control. Stroke (P=0.044) was the only type of CVD that seemed to be significantly associated with good glycemic control. Other factors such as benign prostatic hyperplasia (P=0.026), elderly patients (P=0.018), low-density lipoprotein cholesterol levels (P=0.021), and fasting plasma glucose (P<0.001) were found to be significantly correlated with good glycemic control. Individualized treatment in T2DM patients with CVDs can be supported through a better understanding of the association between glycemic control and CV profiles in T2DM patients.
Publisher: New Zealand: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1177-8881
EISSN: 1177-8881
DOI: 10.2147/DDDT.S87294
PMID: 26316711
Source: DOAJ Directory of Open Access Journals
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
Dove Press Free

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Association between glycemic control and antidiabetic drugs in type 2 diabetes mellitus patients with cardiovascular complications

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