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Arterial Stiffness Increases Over Time in Relation to Lung Diffusion Capacity: A Longitudinal Observation Study in COPD

International journal of chronic obstructive pulmonary disease, 2020-01, Vol.15, p.177-187 [Peer Reviewed Journal]

2020 Roeder et al. ;COPYRIGHT 2020 Dove Medical Press Limited ;COPYRIGHT 2020 Dove Medical Press Limited ;2020. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2020 Roeder et al. 2020 Roeder et al. ;ISSN: 1178-2005 ;ISSN: 1176-9106 ;EISSN: 1178-2005 ;DOI: 10.2147/COPD.S234882 ;PMID: 32158204

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Title:
Arterial Stiffness Increases Over Time in Relation to Lung Diffusion Capacity: A Longitudinal Observation Study in COPD
Author: Roeder, Maurice ; Sievi, Noriane A ; Kohlbrenner, Dario ; Clarenbach, Christian F ; Kohler, Malcolm
Subjects: Aged ; Airway management ; Analysis ; arterial stiffness ; Atherosclerosis ; Blood lipids ; Blood pressure ; C-reactive protein ; Cardiovascular disease ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - physiopathology ; cardiovascular risk ; Chronic obstructive lung disease ; Chronic obstructive pulmonary disease ; copd ; Death ; dyslipidaemia ; Dyslipidemias - complications ; Emphysema ; Exercise ; Female ; Health aspects ; Heart rate ; Humans ; Inflammation ; Inflammation - complications ; Lipids ; longitudinal ; Longitudinal Studies ; Low density lipoproteins ; Lung - physiopathology ; Lung diseases, Obstructive ; Male ; Middle Aged ; Mortality ; Original Research ; Patients ; Physical fitness ; Prospective Studies ; Pulmonary Diffusing Capacity ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Emphysema - complications ; Pulmonary Emphysema - diagnosis ; Pulmonary Emphysema - physiopathology ; Risk Assessment ; Risk Factors ; Setting (Literature) ; Time ; Time Factors ; Vascular Stiffness
Is Part Of: International journal of chronic obstructive pulmonary disease, 2020-01, Vol.15, p.177-187
Description: Cardiovascular events are, after cancer, the most common cause of death in COPD patients. Arterial stiffness is an independent predictor of all-cause mortality and cardiovascular events. Several cross-sectional studies have confirmed increased arterial stiffness in patients with COPD. Various mechanisms in the development of arterial stiffness in COPD such as reduced lung function or systemic inflammation have been proposed. However, clinical predictors of arterial stiffness that had been reported in cross-sectional studies have not yet been confirmed in a longitudinal setting. We have assessed the course of augmentation index (AIx) - a measure of systemic arterial stiffness - and possible predictors in a cohort of COPD patients over a period of up to 7 years. COPD patients underwent annual AIx measurement by applanation tonometry for a maximum duration of 7 years. Additionally, we performed annual assessments of lung function, blood gases, systemic inflammation, serum lipids and blood pressure. Associations between the course of AIx and potential predictors were investigated through a mixed effect model. Seventy-six patients (mean (SD) age 62.4 (7.1), male 67%) were included. The AIx showed a significant annual increase of 0.91% (95% CI 0.21/1.60) adjusted for baseline. The change in diffusion capacity (DLco), low-density lipoprotein (LDL), and high-sensitivity c-reactive protein (hsCRP) was independently associated with the increasing evolution of AIx (Coef. - 0.10, p<0.001, Coef. 1.37, p=0.003, and Coef. 0.07, p=0.033, respectively). This study demonstrated a meaningful increase in arterial stiffness in COPD over time. A greater annual increase in arterial stiffness was associated with the severity of emphysema (measured by DLco), systemic inflammation, and dyslipidaemia. www.ClinicalTrials.gov, NCT01527773.
Publisher: New Zealand: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1178-2005
ISSN: 1176-9106
EISSN: 1178-2005
DOI: 10.2147/COPD.S234882
PMID: 32158204
Source: DOAJ Directory of Open Access Journals
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ProQuest Central
Dove Press Free

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Arterial Stiffness Increases Over Time in Relation to Lung Diffusion Capacity: A Longitudinal Observation Study in COPD

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