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Long-term effects of beta-blocker use on lung function in Japanese patients with chronic obstructive pulmonary disease

International journal of chronic obstructive pulmonary disease, 2017-01, Vol.12, p.1119-1124 [Peer Reviewed Journal]

COPYRIGHT 2017 Dove Medical Press Limited ;COPYRIGHT 2017 Dove Medical Press Limited ;2017. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2017 Oda et al. This work is published and licensed by Dove Medical Press Limited 2017 ;ISSN: 1178-2005 ;ISSN: 1176-9106 ;EISSN: 1178-2005 ;DOI: 10.2147/COPD.S133071 ;PMID: 28435245

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Title:
Long-term effects of beta-blocker use on lung function in Japanese patients with chronic obstructive pulmonary disease
Author: Oda, Naohiro ; Miyahara, Nobuaki ; Ichikawa, Hirohisa ; Tanimoto, Yasushi ; Kajimoto, Kazuhiro ; Sakugawa, Makoto ; Kawai, Haruyuki ; Taniguchi, Akihiko ; Morichika, Daisuke ; Tanimoto, Mitsune ; Kanehiro, Arihiko ; Kiura, Katsuyuki
Subjects: Adrenergic beta blockers ; Adrenergic beta-antagonists ; Adrenergic beta-Antagonists - adverse effects ; Adrenergic beta-Antagonists - therapeutic use ; Adrenergic receptors ; Aged ; Analysis ; Beta blockers ; beta-blocker ; Body mass index ; Cardiovascular disease ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - physiopathology ; Chi-Square Distribution ; Chronic obstructive lung disease ; Chronic obstructive pulmonary disease ; Comorbidity ; Complications and side effects ; Confidence intervals ; Coronary vessels ; Disease Progression ; Dosage and administration ; Drug therapy ; Female ; Forced Expiratory Volume ; forced expiratory volume in 1-second ; Heart failure ; Hospitals ; Humans ; Japan - epidemiology ; Linear Models ; long-term ; Lung - drug effects ; Lung - physiopathology ; Lung diseases ; Lung diseases, Obstructive ; lung function ; Male ; Medical records ; Middle Aged ; Mortality ; Multivariate Analysis ; Original Research ; Patients ; Polypharmacy ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Respiratory therapy ; Retrospective Studies ; Risk Factors ; Smoking ; Spirometry ; Standard deviation ; Steroids ; Time Factors ; Treatment Outcome ; Variables ; Vein & artery diseases ; Vital Capacity
Is Part Of: International journal of chronic obstructive pulmonary disease, 2017-01, Vol.12, p.1119-1124
Description: Some recent studies have suggested that beta-blocker use in patients with chronic obstructive pulmonary disease (COPD) is associated with a reduction in the frequency of acute exacerbations. However, the long-term effects of beta-blocker use on lung function of COPD patients have hardly been evaluated. We retrospectively reviewed 31 Japanese COPD patients taking beta-blockers for >1 year and 72 patients not taking them. The association between beta-blocker use and the annual change in forced expiratory volume in 1 second (FEV1) was assessed. At baseline, patient demographic characteristics were as follows: 97 males (mean age 67.0±8.2 years); 32 current smokers; and Global Initiative for Chronic Obstructive Lung disease (GOLD) stages I: n=26, II: n=52, III: n=19, and IV: n=6. Patients taking beta-blockers exhibited a significantly lower forced vital capacity (FVC), FEV1, and %FVC, and a more advanced GOLD stage. The mean duration of beta-blocker administration was 2.8±1.7 years. There were no differences in the annual change in FEV1 between patients who did and did not use beta-blockers (-7.6±93.5 mL/year vs -4.7±118.9 mL/year, =0.671). After controlling for relevant confounders in multivariate analyses, it was found that beta-blocker use was not significantly associated with the annual decline in FEV1 (β=-0.019; 95% confidence interval: -0.073 to 0.036; =0.503). Long-term beta-blocker use in Japanese COPD patients might not affect the FEV1, one of the most important parameters of lung function in COPD patients.
Publisher: New Zealand: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1178-2005
ISSN: 1176-9106
EISSN: 1178-2005
DOI: 10.2147/COPD.S133071
PMID: 28435245
Source: DOAJ Directory of Open Access Journals
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ProQuest Central
Dove Press Free

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Long-term effects of beta-blocker use on lung function in Japanese patients with chronic obstructive pulmonary disease

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