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Recent progress in bone imaging for osteoporosis research

Journal of bone and mineral metabolism, 2011-03, Vol.29 (2), p.131-140 [Peer Reviewed Journal]

The Japanese Society for Bone and Mineral Research and Springer 2011 ;2015 INIST-CNRS ;ISSN: 0914-8779 ;EISSN: 1435-5604 ;DOI: 10.1007/s00774-010-0258-0 ;PMID: 21301898

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  • Title:
    Recent progress in bone imaging for osteoporosis research
  • Author: Ito, Masako
  • Subjects: Biological and medical sciences ; Bone and Bones - diagnostic imaging ; Bone and Bones - pathology ; computed tomography ; Diseases of the osteoarticular system ; Finite Element Analysis ; Finite element model ; Geometry ; Humans ; Invited Review ; Magnetic resonance ; Magnetic Resonance Imaging ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; microstructure ; Orthopedics ; Osteoporosis - diagnosis ; Osteoporosis - diagnostic imaging ; Osteoporosis. Osteomalacia. Paget disease ; Tomography, X-Ray Computed
  • Is Part Of: Journal of bone and mineral metabolism, 2011-03, Vol.29 (2), p.131-140
  • Description: Advances in bone imaging techniques have provided tools for analyzing bone structure at the macro-, micro- and nano-level. Quantitative assessment of macrostructure can be achieved using dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT), particularly volumetric quantitative CT (vQCT). In vivo quantitative techniques for assessing the microstructure of trabecular bone non-invasively and non-destructively include high-resolution CT (HR-CT) and high-resolution magnetic resonance (HR-MR). Compared with MR imaging, CT-based techniques have the advantage of directly visualizing the bone in the axial skeleton, with high spatial resolution, but the disadvantage of delivering a considerable radiation dose. Micro-CT (μCT), which provides a higher resolution of the microstructure and is principally applicable in vitro, has undergone technological advances such that it is now able to elucidate the physiological skeletal change mechanisms associated with aging and determine the effects of therapeutic intervention on the bone microstructure. In particular, synchrotron μCT (SR-CT) provides a more detailed view of trabecular structure at the nano-level. For the assessment of hip geometry, DXA-based hip structure analysis (HSA) and CT-based HSA have been developed. DXA-based HSA is a convenient tool for analyzing biomechanical properties and for assuming cross-sectional hip geometry based on two-dimensional (2D) data, whereas CT-based HSA provides these parameters three-dimensionally in robust relationship with biomechanical properties, at the cost of greater radiation exposure and the lengthy time required for the analytical procedure. Further progress in bone imaging technology is promising to bring new aspects of bone structure in relation to bone strength to light, and to establish a means for analyzing bone structural properties in the everyday clinical setting.
  • Publisher: Japan: Japan : Springer Japan
  • Language: English
  • Identifier: ISSN: 0914-8779
    EISSN: 1435-5604
    DOI: 10.1007/s00774-010-0258-0
    PMID: 21301898
  • Source: MEDLINE
    Alma/SFX Local Collection
    ProQuest Central
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