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Eldecalcitol is superior to alfacalcidol in maintaining bone mineral density in glucocorticoid-induced osteoporosis patients (e-GLORIA)

Journal of bone and mineral metabolism, 2020-07, Vol.38 (4), p.522-532 [Peer Reviewed Journal]

The Japanese Society Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2020 ;The Japanese Society Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2020. ;ISSN: 0914-8779 ;EISSN: 1435-5604 ;DOI: 10.1007/s00774-020-01091-4 ;PMID: 32140784

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Title:
Eldecalcitol is superior to alfacalcidol in maintaining bone mineral density in glucocorticoid-induced osteoporosis patients (e-GLORIA)
Author: Matsumoto, Toshio ; Yamamoto, Kazuhiko ; Takeuchi, Tsutomu ; Tanaka, Yoshiya ; Tanaka, Sakae ; Nakano, Tetsuo ; Ito, Masako ; Tomomitsu, Tatsushi ; Hirakawa, Akihiro ; Soen, Satoshi
Subjects: Biomarkers - metabolism ; Bone density ; Bone Density - drug effects ; Bone Density Conservation Agents - therapeutic use ; Bone growth ; Bone mineral density ; Bone Remodeling - drug effects ; Bone resorption ; Female ; Femur Neck - drug effects ; Femur Neck - physiopathology ; Fractures ; Glucocorticoids ; Glucocorticoids - adverse effects ; Hip - physiopathology ; Humans ; Hydroxycholecalciferols - adverse effects ; Hydroxycholecalciferols - pharmacology ; Hydroxycholecalciferols - therapeutic use ; Kaplan-Meier Estimate ; Lumbar Vertebrae - drug effects ; Lumbar Vertebrae - physiopathology ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Original Article ; Orthopedics ; Osteogenesis ; Osteoporosis ; Osteoporosis - drug therapy ; Osteoporosis - physiopathology ; Patients ; Spinal Fractures - epidemiology ; Spine (lumbar) ; Vertebrae ; Vitamin D - adverse effects ; Vitamin D - analogs & derivatives ; Vitamin D - pharmacology ; Vitamin D - therapeutic use
Is Part Of: Journal of bone and mineral metabolism, 2020-07, Vol.38 (4), p.522-532
Description: Introduction Eldecalcitol increases bone mineral density (BMD) and reduces vertebral fracture in patients with primary osteoporosis. However, the effect of eldecalcitol on BMD and fracture in glucocorticoid-induced osteoporosis (GIO) patients is unknown. This study was undertaken to compare the effect of eldecalcitol on BMD and fracture with that of alfacalcidol in GIO patients. Materials and methods A randomized, open-label, parallel group study was conducted to identify the effectiveness and safety of monotherapy with 0.75 μg eldecalcitol compared with 1.0 μg alfacalcidol in GIO patients. Results Lumbar spine BMD increased with eldecalcitol, but decreased with alfacalcidol at 12 and 24 months (between group difference 1.29%, p < 0.01, and 1.10%, p < 0.05, respectively). Total hip and femoral neck BMD were maintained until 24 months by eldecalcitol, but decreased by alfacalcidol (between group difference 0.97%, p < 0.05 and 1.22%, p < 0.05, respectively). Both bone formation and resorption markers were more strongly suppressed by eldecalcitol than by alfacalcidol. Eldecalcitol showed better effect on BMD than alfacalcidol in patients with no prevalent fracture and BMD > 70% of the young adult mean, and with ≤ 3 months of previous glucocorticoid treatment. No significant difference in the incidence of vertebral fracture was found, and the incidence of adverse events was similar between the two groups. Conclusions Eldecalcitol was more effective than alfacalcidol in maintaining BMD in GIO patients. Because eldecalcitol was effective in patients with no or short-term previous glucocorticoid treatment, as well as those without prevalent fracture or low BMD, eldecalcitol can be a good candidate for primary prevention of GIO. Clinical trial registration number UMIN000011700.
Publisher: Singapore: Springer Singapore
Language: English
Identifier: ISSN: 0914-8779
EISSN: 1435-5604
DOI: 10.1007/s00774-020-01091-4
PMID: 32140784
Source: AUTh Library subscriptions: ProQuest Central
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Eldecalcitol is superior to alfacalcidol in maintaining bone mineral density in glucocorticoid-induced osteoporosis patients (e-GLORIA)

The Japanese Society Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2020 ;The Japanese Society Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2020. ;ISSN: 0914-8779 ;EISSN: 1435-5604 ;DOI: 10.1007/s00774-020-01091-4 ;PMID: 32140784

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