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Apoptosis: A Target for Anticancer Therapy

International journal of molecular sciences, 2018-02, Vol.19 (2), p.448 [Peer Reviewed Journal]

Copyright MDPI AG 2018 ;2018 by the authors. 2018 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms19020448 ;PMID: 29393886

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  • Title:
    Apoptosis: A Target for Anticancer Therapy
  • Author: Pfeffer, Claire M ; Singh, Amareshwar T K
  • Subjects: anticancer therapy ; Antitumor activity ; Apoptosis ; apoptotic evasion ; Cancer ; Cancer therapies ; Chemotherapy ; curcumin ; Plants ; Proteins ; Review
  • Is Part Of: International journal of molecular sciences, 2018-02, Vol.19 (2), p.448
  • Description: Apoptosis, the cell's natural mechanism for death, is a promising target for anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to carry out apoptosis through the cleavage of hundreds of proteins. In cancer, the apoptotic pathway is typically inhibited through a wide variety of means including overexpression of antiapoptotic proteins and under-expression of proapoptotic proteins. Many of these changes cause intrinsic resistance to the most common anticancer therapy, chemotherapy. Promising new anticancer therapies are plant-derived compounds that exhibit anticancer activity through activating the apoptotic pathway.
  • Publisher: Switzerland: MDPI AG
  • Language: English
  • Identifier: ISSN: 1422-0067
    ISSN: 1661-6596
    EISSN: 1422-0067
    DOI: 10.3390/ijms19020448
    PMID: 29393886
  • Source: PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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