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Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis

International journal of molecular sciences, 2021-02, Vol.22 (4), p.1742 [Peer Reviewed Journal]

2021 by the authors. 2021 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms22041742 ;PMID: 33572320

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  • Title:
    Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis
  • Author: Hu, Qichan ; Ecker, Melanie
  • Subjects: cartilage ; matrix metalloproteinases ; MMP-13 ; osteoarthritis ; regulation ; Review ; type II collagen
  • Is Part Of: International journal of molecular sciences, 2021-02, Vol.22 (4), p.1742
  • Description: Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA. However, the detailed molecular mechanisms of OA initiation and progression remain elusive, and, currently, there are no interventions available to restore degraded cartilage. This review fully illustrates the involvement of MMP-13 in the initiation and progression of OA through the regulation of MMP-13 activity at the molecular and epigenetic levels, as well as the strategies that have been employed against MMP-13. The aim of this review is to identify MMP-13 as an attractive target for inhibitor development in the treatment of OA.
  • Publisher: Switzerland: MDPI
  • Language: English
  • Identifier: ISSN: 1422-0067
    ISSN: 1661-6596
    EISSN: 1422-0067
    DOI: 10.3390/ijms22041742
    PMID: 33572320
  • Source: AUTh Library subscriptions: ProQuest Central
    PubMed Central
    DOAJ Directory of Open Access Journals
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