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Noncoding RNA:RNA Regulatory Networks in Cancer

International journal of molecular sciences, 2018-04, Vol.19 (5), p.1310 [Peer Reviewed Journal]

Copyright MDPI AG 2018 ;2018 by the authors. 2018 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms19051310 ;PMID: 29702599

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  • Title:
    Noncoding RNA:RNA Regulatory Networks in Cancer
  • Author: Chan, Jia Jia ; Tay, Yvonne
  • Subjects: Antisense RNA ; Cancer ; ceRNA ; circRNA ; Computer applications ; Decoys ; Derailments ; Gene expression ; Genomes ; lncRNA ; miRNA ; pseudogene ; Pseudogenes ; Review ; Therapeutic applications
  • Is Part Of: International journal of molecular sciences, 2018-04, Vol.19 (5), p.1310
  • Description: Noncoding RNAs (ncRNAs) constitute the majority of the human transcribed genome. This largest class of RNA transcripts plays diverse roles in a multitude of cellular processes, and has been implicated in many pathological conditions, especially cancer. The different subclasses of ncRNAs include microRNAs, a class of short ncRNAs; and a variety of long ncRNAs (lncRNAs), such as lincRNAs, antisense RNAs, pseudogenes, and circular RNAs. Many studies have demonstrated the involvement of these ncRNAs in competitive regulatory interactions, known as competing endogenous RNA (ceRNA) networks, whereby lncRNAs can act as microRNA decoys to modulate gene expression. These interactions are often interconnected, thus aberrant expression of any network component could derail the complex regulatory circuitry, culminating in cancer development and progression. Recent integrative analyses have provided evidence that new computational platforms and experimental approaches can be harnessed together to distinguish key ceRNA interactions in specific cancers, which could facilitate the identification of robust biomarkers and therapeutic targets, and hence, more effective cancer therapies and better patient outcome and survival.
  • Publisher: Switzerland: MDPI AG
  • Language: English
  • Identifier: ISSN: 1422-0067
    ISSN: 1661-6596
    EISSN: 1422-0067
    DOI: 10.3390/ijms19051310
    PMID: 29702599
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    AUTh Library subscriptions: ProQuest Central
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